Diffuse reflectance spectroscopy for accurate margin assessment in breast-conserving surgeries: importance of an optimal number of fibers

Dinusha Veluponnar*, Behdad Dashtbozorg, Lynn Jade S. Jong, Freija Geldof, Marcos Da Silva Guimaraes, Marie Jeanne T.F.D. Vrancken Peeters, Frederieke Van Duijnhoven, Henricus J.C.M. Sterenborg, Theo J.M. Ruers, Lisanne L. De Boer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

During breast-conserving surgeries, it remains challenging to accomplish adequate surgical margins. We investigated different numbers of fibers for fiber-optic diffuse reflectance spectroscopy to differentiate tumorous breast tissue from healthy tissue ex vivo up to 2 mm from the margin. Using a machine-learning classification model, the optimal performance was obtained using at least three emitting fibers (Matthew's correlation coefficient (MCC) of 0.73), which was significantly higher compared to the performance of using a single-emitting fiber (MCC of 0.48). The percentage of correctly classified tumor locations varied from 75% to 100% depending on the tumor percentage, the tumor-margin distance and the number of fibers.

Original languageEnglish
Pages (from-to)4017-4036
Number of pages20
JournalBiomedical optics express
Volume14
Issue number8
DOIs
Publication statusPublished - Aug 2023

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