TY - JOUR
T1 - Diffuse reflectance spectroscopy for accurate margin assessment in breast-conserving surgeries
T2 - importance of an optimal number of fibers
AU - Veluponnar, Dinusha
AU - Dashtbozorg, Behdad
AU - Jong, Lynn Jade S.
AU - Geldof, Freija
AU - Da Silva Guimaraes, Marcos
AU - Vrancken Peeters, Marie Jeanne T.F.D.
AU - van Duijnhoven, Frederieke
AU - Sterenborg, Henricus J.C.M.
AU - Ruers, Theo J.M.
AU - de Boer, Lisanne L.
N1 - Publisher Copyright:
© 2023 Optica Publishing Group.
PY - 2023/8
Y1 - 2023/8
N2 - During breast-conserving surgeries, it remains challenging to accomplish adequate surgical margins. We investigated different numbers of fibers for fiber-optic diffuse reflectance spectroscopy to differentiate tumorous breast tissue from healthy tissue ex vivo up to 2 mm from the margin. Using a machine-learning classification model, the optimal performance was obtained using at least three emitting fibers (Matthew's correlation coefficient (MCC) of 0.73), which was significantly higher compared to the performance of using a single-emitting fiber (MCC of 0.48). The percentage of correctly classified tumor locations varied from 75% to 100% depending on the tumor percentage, the tumor-margin distance and the number of fibers.
AB - During breast-conserving surgeries, it remains challenging to accomplish adequate surgical margins. We investigated different numbers of fibers for fiber-optic diffuse reflectance spectroscopy to differentiate tumorous breast tissue from healthy tissue ex vivo up to 2 mm from the margin. Using a machine-learning classification model, the optimal performance was obtained using at least three emitting fibers (Matthew's correlation coefficient (MCC) of 0.73), which was significantly higher compared to the performance of using a single-emitting fiber (MCC of 0.48). The percentage of correctly classified tumor locations varied from 75% to 100% depending on the tumor percentage, the tumor-margin distance and the number of fibers.
UR - http://www.scopus.com/inward/record.url?scp=85169040183&partnerID=8YFLogxK
U2 - 10.1364/BOE.493179
DO - 10.1364/BOE.493179
M3 - Article
AN - SCOPUS:85169040183
SN - 2156-7085
VL - 14
SP - 4017
EP - 4036
JO - Biomedical optics express
JF - Biomedical optics express
IS - 8
ER -
