@article{2d303e2395ae4273bd0c1d4d50ca18e8,
title = "Diffuse reflection spectroscopy at the fingertip: design and performance of a compact side-firing probe for tissue discrimination during colorectal cancer surgery",
abstract = "Optical technologies are widely used for tissue sensing purposes. However, maneuvering conventional probe designs with flat-tipped fibers in narrow spaces can be challenging, for instance during pelvic colorectal cancer surgery. In this study, a compact side-firing fiber probe was developed for tissue discrimination during colorectal cancer surgery using diffuse reflectance spectroscopy. The optical behavior was compared to flat-tipped fibers using both Monte Carlo simulations and experimental phantom measurements. The tissue classification performance was examined using freshly excised colorectal cancer specimens. Using the developed probe and classification algorithm, an accuracy of 0.92 was achieved for discriminating tumor tissue from healthy tissue.",
author = "Freija Geldof and Mark Witteveen and Sterenborg, {Henricus J.C.M.} and Ruers, {Theo J.M.} and Behdad Dashtbozorg",
note = "Funding Information: KWF-STW (15228). The authors thank all surgeons and nurses from the Department of Surgery at the Netherlands Cancer Institute for their assistance in collecting the specimens, and all pathologist and pathologist assistants from the Department of Pathology for processing the specimens and obtaining the pathological results. We would also like to thank Dr. Anouk Post for her scientific support and advice, and T. Coenraad for her assistance with the data acquisition. Publisher Copyright: {\textcopyright} 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.",
year = "2023",
month = jan,
day = "1",
doi = "10.1364/BOE.476242",
language = "English",
volume = "14",
pages = "128--147",
journal = "Biomedical optics express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "1",
}
