Diffusion tensor characteristics of gyrencephaly using high resolution diffusion MRI in vivo at 7T

M. Kleinnijenhuis, David Gordon Norris, D.J. Ruiter, A. van Cappelen van Walsum, M. Barth

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

Gyrification of the human cerebral cortex allows for the surface expansion that accommodates many more cortical neurons in comparison to other mammals. For neuroimaging, however, it forms a feature that complicates analysis. For example, it has long been established that cortical layers do not occupy the same depth in gyri and sulci. Recently, in vivo diffusion imaging has provided insights into the fibre architecture of the cortex, usually showing radial tensor orientations. This makes it relevant to investigate whether cortical diffusion tensor metrics depend on the gyral pattern. High-resolution (1 mm isotropic) diffusion weighted MRI of the medial wall of the hemispheres was performed at 7T. Diffusion data were resampled to surfaces in the cortex and underlying white matter, where the cortical surfaces obeyed the equivolume principle for cortical laminae over the cortical curvature. Diffusion tensor metrics were averaged over bins of curvature to obtain maps of characteristic patterns in the gyrus. Diffusivity, anisotropy and radiality varied with curvature. Radiality was maximal in intermediate layers of the cortex next to the crown of the gyrus, not in white matter or on the crown. In the fundus, the deep cortical layers had tangential tensor orientations. In the white matter, tensor orientation changed from radial on the crown to tangential under the banks and fundus. White matter anisotropy gradually increased from the crown to the fundus. The characteristic pattern in the gyrus demonstrated here is in accordance with ex vivo diffusion MR microscopy and histological studies. The results indicate the necessity of taking into account the gyral pattern when cortical diffusion data is analysed. Additionally, the data suggest a confound for tractography approaches when reaching the gyrus, resulting in a possible bias towards the gyral crown. The implications for mechanisms that could drive cortical folding are discussed.
Original languageEnglish
Pages (from-to)378-387
Number of pages10
JournalNeuroImage
Volume109
DOIs
Publication statusPublished - 2015

Fingerprint

Diffusion Magnetic Resonance Imaging
Crowns
Anisotropy
Neuroimaging
Cerebral Cortex
Mammals
Microscopy
Neurons
White Matter

Keywords

  • METIS-312777
  • IR-97858

Cite this

Kleinnijenhuis, M. ; Norris, David Gordon ; Ruiter, D.J. ; van Cappelen van Walsum, A. ; Barth, M. / Diffusion tensor characteristics of gyrencephaly using high resolution diffusion MRI in vivo at 7T. In: NeuroImage. 2015 ; Vol. 109. pp. 378-387.
@article{910dc44ec92540b0b40e179ed55fdfd7,
title = "Diffusion tensor characteristics of gyrencephaly using high resolution diffusion MRI in vivo at 7T",
abstract = "Gyrification of the human cerebral cortex allows for the surface expansion that accommodates many more cortical neurons in comparison to other mammals. For neuroimaging, however, it forms a feature that complicates analysis. For example, it has long been established that cortical layers do not occupy the same depth in gyri and sulci. Recently, in vivo diffusion imaging has provided insights into the fibre architecture of the cortex, usually showing radial tensor orientations. This makes it relevant to investigate whether cortical diffusion tensor metrics depend on the gyral pattern. High-resolution (1 mm isotropic) diffusion weighted MRI of the medial wall of the hemispheres was performed at 7T. Diffusion data were resampled to surfaces in the cortex and underlying white matter, where the cortical surfaces obeyed the equivolume principle for cortical laminae over the cortical curvature. Diffusion tensor metrics were averaged over bins of curvature to obtain maps of characteristic patterns in the gyrus. Diffusivity, anisotropy and radiality varied with curvature. Radiality was maximal in intermediate layers of the cortex next to the crown of the gyrus, not in white matter or on the crown. In the fundus, the deep cortical layers had tangential tensor orientations. In the white matter, tensor orientation changed from radial on the crown to tangential under the banks and fundus. White matter anisotropy gradually increased from the crown to the fundus. The characteristic pattern in the gyrus demonstrated here is in accordance with ex vivo diffusion MR microscopy and histological studies. The results indicate the necessity of taking into account the gyral pattern when cortical diffusion data is analysed. Additionally, the data suggest a confound for tractography approaches when reaching the gyrus, resulting in a possible bias towards the gyral crown. The implications for mechanisms that could drive cortical folding are discussed.",
keywords = "METIS-312777, IR-97858",
author = "M. Kleinnijenhuis and Norris, {David Gordon} and D.J. Ruiter and {van Cappelen van Walsum}, A. and M. Barth",
year = "2015",
doi = "10.1016/j.neuroimage.2015.01.001",
language = "English",
volume = "109",
pages = "378--387",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

Diffusion tensor characteristics of gyrencephaly using high resolution diffusion MRI in vivo at 7T. / Kleinnijenhuis, M.; Norris, David Gordon; Ruiter, D.J.; van Cappelen van Walsum, A.; Barth, M.

In: NeuroImage, Vol. 109, 2015, p. 378-387.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Diffusion tensor characteristics of gyrencephaly using high resolution diffusion MRI in vivo at 7T

AU - Kleinnijenhuis, M.

AU - Norris, David Gordon

AU - Ruiter, D.J.

AU - van Cappelen van Walsum, A.

AU - Barth, M.

PY - 2015

Y1 - 2015

N2 - Gyrification of the human cerebral cortex allows for the surface expansion that accommodates many more cortical neurons in comparison to other mammals. For neuroimaging, however, it forms a feature that complicates analysis. For example, it has long been established that cortical layers do not occupy the same depth in gyri and sulci. Recently, in vivo diffusion imaging has provided insights into the fibre architecture of the cortex, usually showing radial tensor orientations. This makes it relevant to investigate whether cortical diffusion tensor metrics depend on the gyral pattern. High-resolution (1 mm isotropic) diffusion weighted MRI of the medial wall of the hemispheres was performed at 7T. Diffusion data were resampled to surfaces in the cortex and underlying white matter, where the cortical surfaces obeyed the equivolume principle for cortical laminae over the cortical curvature. Diffusion tensor metrics were averaged over bins of curvature to obtain maps of characteristic patterns in the gyrus. Diffusivity, anisotropy and radiality varied with curvature. Radiality was maximal in intermediate layers of the cortex next to the crown of the gyrus, not in white matter or on the crown. In the fundus, the deep cortical layers had tangential tensor orientations. In the white matter, tensor orientation changed from radial on the crown to tangential under the banks and fundus. White matter anisotropy gradually increased from the crown to the fundus. The characteristic pattern in the gyrus demonstrated here is in accordance with ex vivo diffusion MR microscopy and histological studies. The results indicate the necessity of taking into account the gyral pattern when cortical diffusion data is analysed. Additionally, the data suggest a confound for tractography approaches when reaching the gyrus, resulting in a possible bias towards the gyral crown. The implications for mechanisms that could drive cortical folding are discussed.

AB - Gyrification of the human cerebral cortex allows for the surface expansion that accommodates many more cortical neurons in comparison to other mammals. For neuroimaging, however, it forms a feature that complicates analysis. For example, it has long been established that cortical layers do not occupy the same depth in gyri and sulci. Recently, in vivo diffusion imaging has provided insights into the fibre architecture of the cortex, usually showing radial tensor orientations. This makes it relevant to investigate whether cortical diffusion tensor metrics depend on the gyral pattern. High-resolution (1 mm isotropic) diffusion weighted MRI of the medial wall of the hemispheres was performed at 7T. Diffusion data were resampled to surfaces in the cortex and underlying white matter, where the cortical surfaces obeyed the equivolume principle for cortical laminae over the cortical curvature. Diffusion tensor metrics were averaged over bins of curvature to obtain maps of characteristic patterns in the gyrus. Diffusivity, anisotropy and radiality varied with curvature. Radiality was maximal in intermediate layers of the cortex next to the crown of the gyrus, not in white matter or on the crown. In the fundus, the deep cortical layers had tangential tensor orientations. In the white matter, tensor orientation changed from radial on the crown to tangential under the banks and fundus. White matter anisotropy gradually increased from the crown to the fundus. The characteristic pattern in the gyrus demonstrated here is in accordance with ex vivo diffusion MR microscopy and histological studies. The results indicate the necessity of taking into account the gyral pattern when cortical diffusion data is analysed. Additionally, the data suggest a confound for tractography approaches when reaching the gyrus, resulting in a possible bias towards the gyral crown. The implications for mechanisms that could drive cortical folding are discussed.

KW - METIS-312777

KW - IR-97858

U2 - 10.1016/j.neuroimage.2015.01.001

DO - 10.1016/j.neuroimage.2015.01.001

M3 - Article

VL - 109

SP - 378

EP - 387

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -