Diffusion tensor magnetic resonance imaging and fiber tractography of the sacral plexusin children with spina bifida

W. Haakma, P. Dik, Bernard ten Haken, M. Froeling, R.A.J. Nievelstein, I. Cuppen, T.P.V.M. De Jong, A. Leemans

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Abstract

Purpose It is still largely unknown how neural tube defects in spina bifida affect the nerves at the level of the sacral plexus. Visualizing the sacral plexus in 3 dimensions could improve our anatomical understanding of neurological problems in patients with spina bifida. We investigated anatomical and microstructural properties of the sacral plexus of patients with spina bifida using diffusion tensor imaging and fiber tractography. Materials and Methods Ten patients 8 to 16 years old with spina bifida underwent diffusion tensor imaging on a 3 Tesla magnetic resonance imaging system. Anatomical 3-dimensional reconstructions were obtained of the sacral plexus of the 10 patients. Fiber tractography was performed with a diffusion magnetic resonance imaging toolbox to determine fractional anisotropy, and mean, axial and radial diffusivity in the sacral plexus of the patients. Results were compared to 10 healthy controls. Results Nerves of patients with spina bifida showed asymmetry and disorganization to a large extent compared to those of healthy controls. Especially at the myelomeningocele level it was difficult to find a connection with the cauda equina. Mean, axial and radial diffusivity values at S1-S3 were significantly lower in patients. Conclusions To our knowledge this 3 Tesla magnetic resonance imaging study showed for the first time sacral plexus asymmetry and disorganization in 10 patients with spina bifida using diffusion tensor imaging and fiber tractography. The observed difference in diffusion values indicates that these methods may be used to identify nerve abnormalities. We expect that this technique could provide a valuable contribution to better analysis and understanding of the problems of patients with spina bifida in the future. Key Words urinary bladder; spinal dysraphism; lumbosacral plexus; diffusion tensor imaging; diagnostic imaging Abbreviations and Acronyms 3D, 3-dimensional; AD, axial diffusivity; DTI, diffusion tensor imaging; FA, fractional anisotropy; FT, fiber tractography; MD, mean diffusivity; MRI, magnetic resonance imaging; RD, radial diffusivity; ROI, region of interest; SB, spina bifida; TSE, turbo spin-echo
Original languageEnglish
Pages (from-to)927-933
JournalJournal of urology
Volume192
Issue number3
DOIs
Publication statusPublished - 21 Apr 2014

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Spinal Dysraphism
Diffusion Magnetic Resonance Imaging
Lumbosacral Plexus
Diffusion Tensor Imaging
Anisotropy
Magnetic Resonance Imaging
Cauda Equina
Meningomyelocele
Neural Tube Defects
Urinary Bladder

Keywords

  • IR-94654
  • METIS-309505

Cite this

Haakma, W. ; Dik, P. ; ten Haken, Bernard ; Froeling, M. ; Nievelstein, R.A.J. ; Cuppen, I. ; De Jong, T.P.V.M. ; Leemans, A. / Diffusion tensor magnetic resonance imaging and fiber tractography of the sacral plexusin children with spina bifida. In: Journal of urology. 2014 ; Vol. 192, No. 3. pp. 927-933.
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title = "Diffusion tensor magnetic resonance imaging and fiber tractography of the sacral plexusin children with spina bifida",
abstract = "Purpose It is still largely unknown how neural tube defects in spina bifida affect the nerves at the level of the sacral plexus. Visualizing the sacral plexus in 3 dimensions could improve our anatomical understanding of neurological problems in patients with spina bifida. We investigated anatomical and microstructural properties of the sacral plexus of patients with spina bifida using diffusion tensor imaging and fiber tractography. Materials and Methods Ten patients 8 to 16 years old with spina bifida underwent diffusion tensor imaging on a 3 Tesla magnetic resonance imaging system. Anatomical 3-dimensional reconstructions were obtained of the sacral plexus of the 10 patients. Fiber tractography was performed with a diffusion magnetic resonance imaging toolbox to determine fractional anisotropy, and mean, axial and radial diffusivity in the sacral plexus of the patients. Results were compared to 10 healthy controls. Results Nerves of patients with spina bifida showed asymmetry and disorganization to a large extent compared to those of healthy controls. Especially at the myelomeningocele level it was difficult to find a connection with the cauda equina. Mean, axial and radial diffusivity values at S1-S3 were significantly lower in patients. Conclusions To our knowledge this 3 Tesla magnetic resonance imaging study showed for the first time sacral plexus asymmetry and disorganization in 10 patients with spina bifida using diffusion tensor imaging and fiber tractography. The observed difference in diffusion values indicates that these methods may be used to identify nerve abnormalities. We expect that this technique could provide a valuable contribution to better analysis and understanding of the problems of patients with spina bifida in the future. Key Words urinary bladder; spinal dysraphism; lumbosacral plexus; diffusion tensor imaging; diagnostic imaging Abbreviations and Acronyms 3D, 3-dimensional; AD, axial diffusivity; DTI, diffusion tensor imaging; FA, fractional anisotropy; FT, fiber tractography; MD, mean diffusivity; MRI, magnetic resonance imaging; RD, radial diffusivity; ROI, region of interest; SB, spina bifida; TSE, turbo spin-echo",
keywords = "IR-94654, METIS-309505",
author = "W. Haakma and P. Dik and {ten Haken}, Bernard and M. Froeling and R.A.J. Nievelstein and I. Cuppen and {De Jong}, T.P.V.M. and A. Leemans",
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Haakma, W, Dik, P, ten Haken, B, Froeling, M, Nievelstein, RAJ, Cuppen, I, De Jong, TPVM & Leemans, A 2014, 'Diffusion tensor magnetic resonance imaging and fiber tractography of the sacral plexusin children with spina bifida' Journal of urology, vol. 192, no. 3, pp. 927-933. https://doi.org/10.1016/j.juro.2014.02.2581

Diffusion tensor magnetic resonance imaging and fiber tractography of the sacral plexusin children with spina bifida. / Haakma, W.; Dik, P.; ten Haken, Bernard; Froeling, M.; Nievelstein, R.A.J.; Cuppen, I.; De Jong, T.P.V.M.; Leemans, A.

In: Journal of urology, Vol. 192, No. 3, 21.04.2014, p. 927-933.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Diffusion tensor magnetic resonance imaging and fiber tractography of the sacral plexusin children with spina bifida

AU - Haakma, W.

AU - Dik, P.

AU - ten Haken, Bernard

AU - Froeling, M.

AU - Nievelstein, R.A.J.

AU - Cuppen, I.

AU - De Jong, T.P.V.M.

AU - Leemans, A.

N1 - Michael Mitchell Editorial Comment The Journal of Urology, Volume 192, Issue 3, September 2014, Page 933

PY - 2014/4/21

Y1 - 2014/4/21

N2 - Purpose It is still largely unknown how neural tube defects in spina bifida affect the nerves at the level of the sacral plexus. Visualizing the sacral plexus in 3 dimensions could improve our anatomical understanding of neurological problems in patients with spina bifida. We investigated anatomical and microstructural properties of the sacral plexus of patients with spina bifida using diffusion tensor imaging and fiber tractography. Materials and Methods Ten patients 8 to 16 years old with spina bifida underwent diffusion tensor imaging on a 3 Tesla magnetic resonance imaging system. Anatomical 3-dimensional reconstructions were obtained of the sacral plexus of the 10 patients. Fiber tractography was performed with a diffusion magnetic resonance imaging toolbox to determine fractional anisotropy, and mean, axial and radial diffusivity in the sacral plexus of the patients. Results were compared to 10 healthy controls. Results Nerves of patients with spina bifida showed asymmetry and disorganization to a large extent compared to those of healthy controls. Especially at the myelomeningocele level it was difficult to find a connection with the cauda equina. Mean, axial and radial diffusivity values at S1-S3 were significantly lower in patients. Conclusions To our knowledge this 3 Tesla magnetic resonance imaging study showed for the first time sacral plexus asymmetry and disorganization in 10 patients with spina bifida using diffusion tensor imaging and fiber tractography. The observed difference in diffusion values indicates that these methods may be used to identify nerve abnormalities. We expect that this technique could provide a valuable contribution to better analysis and understanding of the problems of patients with spina bifida in the future. Key Words urinary bladder; spinal dysraphism; lumbosacral plexus; diffusion tensor imaging; diagnostic imaging Abbreviations and Acronyms 3D, 3-dimensional; AD, axial diffusivity; DTI, diffusion tensor imaging; FA, fractional anisotropy; FT, fiber tractography; MD, mean diffusivity; MRI, magnetic resonance imaging; RD, radial diffusivity; ROI, region of interest; SB, spina bifida; TSE, turbo spin-echo

AB - Purpose It is still largely unknown how neural tube defects in spina bifida affect the nerves at the level of the sacral plexus. Visualizing the sacral plexus in 3 dimensions could improve our anatomical understanding of neurological problems in patients with spina bifida. We investigated anatomical and microstructural properties of the sacral plexus of patients with spina bifida using diffusion tensor imaging and fiber tractography. Materials and Methods Ten patients 8 to 16 years old with spina bifida underwent diffusion tensor imaging on a 3 Tesla magnetic resonance imaging system. Anatomical 3-dimensional reconstructions were obtained of the sacral plexus of the 10 patients. Fiber tractography was performed with a diffusion magnetic resonance imaging toolbox to determine fractional anisotropy, and mean, axial and radial diffusivity in the sacral plexus of the patients. Results were compared to 10 healthy controls. Results Nerves of patients with spina bifida showed asymmetry and disorganization to a large extent compared to those of healthy controls. Especially at the myelomeningocele level it was difficult to find a connection with the cauda equina. Mean, axial and radial diffusivity values at S1-S3 were significantly lower in patients. Conclusions To our knowledge this 3 Tesla magnetic resonance imaging study showed for the first time sacral plexus asymmetry and disorganization in 10 patients with spina bifida using diffusion tensor imaging and fiber tractography. The observed difference in diffusion values indicates that these methods may be used to identify nerve abnormalities. We expect that this technique could provide a valuable contribution to better analysis and understanding of the problems of patients with spina bifida in the future. Key Words urinary bladder; spinal dysraphism; lumbosacral plexus; diffusion tensor imaging; diagnostic imaging Abbreviations and Acronyms 3D, 3-dimensional; AD, axial diffusivity; DTI, diffusion tensor imaging; FA, fractional anisotropy; FT, fiber tractography; MD, mean diffusivity; MRI, magnetic resonance imaging; RD, radial diffusivity; ROI, region of interest; SB, spina bifida; TSE, turbo spin-echo

KW - IR-94654

KW - METIS-309505

U2 - 10.1016/j.juro.2014.02.2581

DO - 10.1016/j.juro.2014.02.2581

M3 - Article

VL - 192

SP - 927

EP - 933

JO - Journal of urology

JF - Journal of urology

SN - 0022-5347

IS - 3

ER -