Discriminating between absorption and scattering coefficients in optical characterisation measurements on gold nanoparticle based photoacoustic contrast agents

C. Ungureanu, Srirang Manohar, Ton van Leeuwen, A. Amelink, Henricus J.C.M. Sterenborg

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Plasmon resonant nanoparticles such as gold nanoshells and gold nanorods can be tuned to possess sharp interaction peaks in the near-infrared wavelength regions. These have great importance as contrast agents in photoacoustic imaging and as photothermal agents for therapeutic applications due to their high absorptions. While the optical properties of the particles are can be described using Mie theory and/or numerical methods such as the Discrete Dipole Approximation, discriminating between their optical absorption and scattering in experiments is not easy. In this paper we discuss for the first time a novel method based on a two-fiber spectrometer that allows measurement of the scattering and absorption coefficients of gold nanoparticles in solution. This technique, called Differential Path length Spectroscopy, has been developed earlier for measurement in highly diffusive media such as tissue. We demonstrate this concept on gold nanospheres and nanoshells of various sizes. We believe that this will develop into a fast and reliable method able to work on small samples (<1 ml) of nanoparticles to obtain scattering and absorbing spectra
Original languageUndefined
Title of host publicationPhotons Plus Ultrasound: Imaging and Sensing 2009
EditorsAlexander A. Oraevsky, Lihong V. Wang
Place of PublicationBellingham
ISBN (Print)9780819474230
Publication statusPublished - 24 Jan 2009
EventSPIE International Symposium on Biomedical Optics, BIOS 2009 - San Jose, United States
Duration: 24 Jan 200929 Jan 2009

Publication series

NameProceedings of SPIE
ISSN (Print)1605-7422


ConferenceSPIE International Symposium on Biomedical Optics, BIOS 2009
Country/TerritoryUnited States
CitySan Jose


  • METIS-258864
  • differential path lengthspectroscopy
  • Optical properties
  • Photoacoustic imaging
  • Gold nanoparticles
  • Contrast agents
  • IR-77977

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