Discrimination between Doppler-shifted and non-shifted light in coherence domain path length resolved measurements of multiply scattered light

Babu Varghese, Vinayakrishnan Rajan, Ton van Leeuwen, Wiendelt Steenbergen

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Abstract

We show a novel technique to distinguish between Doppler shifted and unshifted light in multiple scattering experiments on mixed static and dynamic media. With a phase modulated low coherence Mach- Zehnder interferometer, optical path lengths of shifted and unshifted light and path length dependent Doppler broadening are measured in a two-layer tissue phantom, with a superficial static layer of different thickness covering a semi-infinite dynamic medium having identical optical properties. No Doppler broadening is observed until a certain optical path length depending on the thickness of the superficial static layer. From the minimum optical path length corresponding to the Doppler-shifted light the thickness of the static layer that overlies the dynamic layer can be estimated. Validation of the experimentally determined thickness of the static layer is done with the Doppler Monte Carlo technique. This approach has potential applications in discriminating between statically and dynamically scattered light in the perfusion signal and in determining superficial burn depths
Original languageEnglish
Pages (from-to)13340-13350
Number of pages11
JournalOptics express
Volume15
Issue number20
DOIs
Publication statusPublished - 2007

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discrimination
optical paths
Mach-Zehnder interferometers
coverings
optical properties
scattering

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title = "Discrimination between Doppler-shifted and non-shifted light in coherence domain path length resolved measurements of multiply scattered light",
abstract = "We show a novel technique to distinguish between Doppler shifted and unshifted light in multiple scattering experiments on mixed static and dynamic media. With a phase modulated low coherence Mach- Zehnder interferometer, optical path lengths of shifted and unshifted light and path length dependent Doppler broadening are measured in a two-layer tissue phantom, with a superficial static layer of different thickness covering a semi-infinite dynamic medium having identical optical properties. No Doppler broadening is observed until a certain optical path length depending on the thickness of the superficial static layer. From the minimum optical path length corresponding to the Doppler-shifted light the thickness of the static layer that overlies the dynamic layer can be estimated. Validation of the experimentally determined thickness of the static layer is done with the Doppler Monte Carlo technique. This approach has potential applications in discriminating between statically and dynamically scattered light in the perfusion signal and in determining superficial burn depths",
author = "Babu Varghese and Vinayakrishnan Rajan and {van Leeuwen}, Ton and Wiendelt Steenbergen",
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Discrimination between Doppler-shifted and non-shifted light in coherence domain path length resolved measurements of multiply scattered light. / Varghese, Babu; Rajan, Vinayakrishnan; van Leeuwen, Ton; Steenbergen, Wiendelt.

In: Optics express, Vol. 15, No. 20, 2007, p. 13340-13350.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Discrimination between Doppler-shifted and non-shifted light in coherence domain path length resolved measurements of multiply scattered light

AU - Varghese, Babu

AU - Rajan, Vinayakrishnan

AU - van Leeuwen, Ton

AU - Steenbergen, Wiendelt

PY - 2007

Y1 - 2007

N2 - We show a novel technique to distinguish between Doppler shifted and unshifted light in multiple scattering experiments on mixed static and dynamic media. With a phase modulated low coherence Mach- Zehnder interferometer, optical path lengths of shifted and unshifted light and path length dependent Doppler broadening are measured in a two-layer tissue phantom, with a superficial static layer of different thickness covering a semi-infinite dynamic medium having identical optical properties. No Doppler broadening is observed until a certain optical path length depending on the thickness of the superficial static layer. From the minimum optical path length corresponding to the Doppler-shifted light the thickness of the static layer that overlies the dynamic layer can be estimated. Validation of the experimentally determined thickness of the static layer is done with the Doppler Monte Carlo technique. This approach has potential applications in discriminating between statically and dynamically scattered light in the perfusion signal and in determining superficial burn depths

AB - We show a novel technique to distinguish between Doppler shifted and unshifted light in multiple scattering experiments on mixed static and dynamic media. With a phase modulated low coherence Mach- Zehnder interferometer, optical path lengths of shifted and unshifted light and path length dependent Doppler broadening are measured in a two-layer tissue phantom, with a superficial static layer of different thickness covering a semi-infinite dynamic medium having identical optical properties. No Doppler broadening is observed until a certain optical path length depending on the thickness of the superficial static layer. From the minimum optical path length corresponding to the Doppler-shifted light the thickness of the static layer that overlies the dynamic layer can be estimated. Validation of the experimentally determined thickness of the static layer is done with the Doppler Monte Carlo technique. This approach has potential applications in discriminating between statically and dynamically scattered light in the perfusion signal and in determining superficial burn depths

U2 - 10.1364/OE.15.013340

DO - 10.1364/OE.15.013340

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SP - 13340

EP - 13350

JO - Optics express

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SN - 1094-4087

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