Dissociable laminar profiles of concurrent bottom-up and top-down modulation in the human visual cortex

Samuel J.D. Lawrence, David G. Norris, Floris P. De Lange*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
22 Downloads (Pure)

Abstract

Recent developments in human neuroimaging make it possible to non-invasively measure neural activity from different cortical layers. This can potentially reveal not only which brain areas are engaged by a task, but also how. Specifically, bottom-up and top-down responses are associated with distinct laminar profiles. Here, we measured lamina-resolved fMRI responses during a visual task designed to induce concurrent bottom-up and top-down modulations via orthogonal manipulations of stimulus contrast and feature-based attention. BOLD responses were modulated by both stimulus contrast (bottom-up) and by engaging feature-based attention (topdown). Crucially, these effects operated at different cortical depths: Bottom-up modulations were strongest in the middle cortical layer and weaker in deep and superficial layers, while top-down modulations were strongest in the superficial layers. As such, we demonstrate that laminar activity profiles can discriminate between concurrent top-down and bottom-up processing, and are diagnostic of how a brain region is activated.

Original languageEnglish
Article numbere44422
JournaleLife
Volume8
Early online date7 May 2019
DOIs
Publication statusPublished - 7 May 2019

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