Abstract
The tegmental nucleus pedunculopontinus proves to connect by acetylcholine neurotransmitters, among others, the subthalamic nucleus. Dissociated cultures of the subthalamic nucleus on micro-electrode arrays were studied by addition of acetylcholine and by stimulation. Addition of acetylcholine had no effect on bursting activity, reduced spike activity strongly for a short period, after which activity increased again, but overall activity was reduced over time with 25%. After termination of acetylcholine addition the activity returned to normal.
Original language | Undefined |
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Title of host publication | XII Mediterranean Conference on Medical and Biological Engineering and Computing |
Place of Publication | Heidelberg |
Publisher | Springer |
Pages | 180-183 |
Number of pages | 4 |
ISBN (Print) | 978-3-642-13038-0 |
DOIs | |
Publication status | Published - 27 May 2010 |
Event | XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 - Chalkidiki, Greece, Chalcidice, Greece Duration: 27 May 2010 → 30 May 2010 Conference number: 12 http://www.medicon2010.org/ |
Publication series
Name | IFMBE Proceedings |
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Publisher | Springer Verlag |
Number | 29 |
Volume | 29 |
ISSN (Print) | 1680-0737 |
ISSN (Electronic) | 1433-9277 |
Conference
Conference | XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 |
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Abbreviated title | MEDICON 2010 |
Country/Territory | Greece |
City | Chalcidice |
Period | 27/05/10 → 30/05/10 |
Other | 27-30 May 2010 |
Internet address |
Keywords
- METIS-270971
- IR-72538
- acetylcholine
- EWI-18279
- subthalamic area
- Parkinson’s disease
- Dissociated neurons