Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    The tegmental nucleus pedunculopontinus proves to connect by acetylcholine neurotransmitters, among others, the subthalamic nucleus. Dissociated cultures of the subthalamic nucleus on micro-electrode arrays were studied by addition of acetylcholine and by stimulation. Addition of acetylcholine had no effect on bursting activity, reduced spike activity strongly for a short period, after which activity increased again, but overall activity was reduced over time with 25%. After termination of acetylcholine addition the activity returned to normal.
    Original languageUndefined
    Title of host publicationXII Mediterranean Conference on Medical and Biological Engineering and Computing
    Place of PublicationHeidelberg
    PublisherSpringer
    Pages180-183
    Number of pages4
    ISBN (Print)978-3-642-13038-0
    DOIs
    Publication statusPublished - 27 May 2010
    EventXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 - Chalkidiki, Greece, Chalcidice, Greece
    Duration: 27 May 201030 May 2010
    Conference number: 12
    http://www.medicon2010.org/

    Publication series

    NameIFMBE Proceedings
    PublisherSpringer Verlag
    Number29
    Volume29
    ISSN (Print)1680-0737
    ISSN (Electronic)1433-9277

    Conference

    ConferenceXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010
    Abbreviated titleMEDICON 2010
    CountryGreece
    CityChalcidice
    Period27/05/1030/05/10
    Other27-30 May 2010
    Internet address

    Keywords

    • METIS-270971
    • IR-72538
    • acetylcholine
    • EWI-18279
    • subthalamic area
    • Parkinson’s disease
    • Dissociated neurons

    Cite this

    Heida, T., & Marani, E. (2010). Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. In XII Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 180-183). (IFMBE Proceedings; Vol. 29, No. 29). Heidelberg: Springer. https://doi.org/10.1007/978-3-642-13039-7_45