Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

The tegmental nucleus pedunculopontinus proves to connect by acetylcholine neurotransmitters, among others, the subthalamic nucleus. Dissociated cultures of the subthalamic nucleus on micro-electrode arrays were studied by addition of acetylcholine and by stimulation. Addition of acetylcholine had no effect on bursting activity, reduced spike activity strongly for a short period, after which activity increased again, but overall activity was reduced over time with 25%. After termination of acetylcholine addition the activity returned to normal.
Original languageUndefined
Title of host publicationXII Mediterranean Conference on Medical and Biological Engineering and Computing
Place of PublicationHeidelberg
PublisherSpringer
Pages180-183
Number of pages4
ISBN (Print)978-3-642-13038-0
DOIs
Publication statusPublished - 27 May 2010
EventXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 - Chalkidiki, Greece, Chalcidice, Greece
Duration: 27 May 201030 May 2010
Conference number: 12
http://www.medicon2010.org/

Publication series

NameIFMBE Proceedings
PublisherSpringer Verlag
Number29
Volume29
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277

Conference

ConferenceXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010
Abbreviated titleMEDICON 2010
CountryGreece
CityChalcidice
Period27/05/1030/05/10
Other27-30 May 2010
Internet address

Keywords

  • METIS-270971
  • IR-72538
  • acetylcholine
  • EWI-18279
  • subthalamic area
  • Parkinson’s disease
  • Dissociated neurons

Cite this

Heida, T., & Marani, E. (2010). Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. In XII Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 180-183). (IFMBE Proceedings; Vol. 29, No. 29). Heidelberg: Springer. https://doi.org/10.1007/978-3-642-13039-7_45
Heida, Tjitske ; Marani, Enrico. / Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. XII Mediterranean Conference on Medical and Biological Engineering and Computing. Heidelberg : Springer, 2010. pp. 180-183 (IFMBE Proceedings; 29).
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abstract = "The tegmental nucleus pedunculopontinus proves to connect by acetylcholine neurotransmitters, among others, the subthalamic nucleus. Dissociated cultures of the subthalamic nucleus on micro-electrode arrays were studied by addition of acetylcholine and by stimulation. Addition of acetylcholine had no effect on bursting activity, reduced spike activity strongly for a short period, after which activity increased again, but overall activity was reduced over time with 25{\%}. After termination of acetylcholine addition the activity returned to normal.",
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Heida, T & Marani, E 2010, Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. in XII Mediterranean Conference on Medical and Biological Engineering and Computing. IFMBE Proceedings, no. 29, vol. 29, Springer, Heidelberg, pp. 180-183, XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, Chalcidice, Greece, 27/05/10. https://doi.org/10.1007/978-3-642-13039-7_45

Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. / Heida, Tjitske; Marani, Enrico.

XII Mediterranean Conference on Medical and Biological Engineering and Computing. Heidelberg : Springer, 2010. p. 180-183 (IFMBE Proceedings; Vol. 29, No. 29).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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AB - The tegmental nucleus pedunculopontinus proves to connect by acetylcholine neurotransmitters, among others, the subthalamic nucleus. Dissociated cultures of the subthalamic nucleus on micro-electrode arrays were studied by addition of acetylcholine and by stimulation. Addition of acetylcholine had no effect on bursting activity, reduced spike activity strongly for a short period, after which activity increased again, but overall activity was reduced over time with 25%. After termination of acetylcholine addition the activity returned to normal.

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Heida T, Marani E. Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. In XII Mediterranean Conference on Medical and Biological Engineering and Computing. Heidelberg: Springer. 2010. p. 180-183. (IFMBE Proceedings; 29). https://doi.org/10.1007/978-3-642-13039-7_45