Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    The tegmental nucleus pedunculopontinus proves to connect by acetylcholine neurotransmitters, among others, the subthalamic nucleus. Dissociated cultures of the subthalamic nucleus on micro-electrode arrays were studied by addition of acetylcholine and by stimulation. Addition of acetylcholine had no effect on bursting activity, reduced spike activity strongly for a short period, after which activity increased again, but overall activity was reduced over time with 25%. After termination of acetylcholine addition the activity returned to normal.
    Original languageUndefined
    Title of host publicationXII Mediterranean Conference on Medical and Biological Engineering and Computing
    Place of PublicationHeidelberg
    PublisherSpringer
    Pages180-183
    Number of pages4
    ISBN (Print)978-3-642-13038-0
    DOIs
    Publication statusPublished - 27 May 2010
    EventXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 - Chalkidiki, Greece, Chalcidice, Greece
    Duration: 27 May 201030 May 2010
    Conference number: 12
    http://www.medicon2010.org/

    Publication series

    NameIFMBE Proceedings
    PublisherSpringer Verlag
    Number29
    Volume29
    ISSN (Print)1680-0737
    ISSN (Electronic)1433-9277

    Conference

    ConferenceXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010
    Abbreviated titleMEDICON 2010
    CountryGreece
    CityChalcidice
    Period27/05/1030/05/10
    Other27-30 May 2010
    Internet address

    Keywords

    • METIS-270971
    • IR-72538
    • acetylcholine
    • EWI-18279
    • subthalamic area
    • Parkinson’s disease
    • Dissociated neurons

    Cite this

    Heida, T., & Marani, E. (2010). Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. In XII Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 180-183). (IFMBE Proceedings; Vol. 29, No. 29). Heidelberg: Springer. https://doi.org/10.1007/978-3-642-13039-7_45
    Heida, Tjitske ; Marani, Enrico. / Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. XII Mediterranean Conference on Medical and Biological Engineering and Computing. Heidelberg : Springer, 2010. pp. 180-183 (IFMBE Proceedings; 29).
    @inproceedings{61c3e03b0d2c4849888d48accfe190c9,
    title = "Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition",
    abstract = "The tegmental nucleus pedunculopontinus proves to connect by acetylcholine neurotransmitters, among others, the subthalamic nucleus. Dissociated cultures of the subthalamic nucleus on micro-electrode arrays were studied by addition of acetylcholine and by stimulation. Addition of acetylcholine had no effect on bursting activity, reduced spike activity strongly for a short period, after which activity increased again, but overall activity was reduced over time with 25{\%}. After termination of acetylcholine addition the activity returned to normal.",
    keywords = "METIS-270971, IR-72538, acetylcholine, EWI-18279, subthalamic area, Parkinson’s disease, Dissociated neurons",
    author = "Tjitske Heida and Enrico Marani",
    note = "10.1007/978-3-642-13039-7_45",
    year = "2010",
    month = "5",
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    doi = "10.1007/978-3-642-13039-7_45",
    language = "Undefined",
    isbn = "978-3-642-13038-0",
    series = "IFMBE Proceedings",
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    }

    Heida, T & Marani, E 2010, Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. in XII Mediterranean Conference on Medical and Biological Engineering and Computing. IFMBE Proceedings, no. 29, vol. 29, Springer, Heidelberg, pp. 180-183, XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, Chalcidice, Greece, 27/05/10. https://doi.org/10.1007/978-3-642-13039-7_45

    Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. / Heida, Tjitske; Marani, Enrico.

    XII Mediterranean Conference on Medical and Biological Engineering and Computing. Heidelberg : Springer, 2010. p. 180-183 (IFMBE Proceedings; Vol. 29, No. 29).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    N2 - The tegmental nucleus pedunculopontinus proves to connect by acetylcholine neurotransmitters, among others, the subthalamic nucleus. Dissociated cultures of the subthalamic nucleus on micro-electrode arrays were studied by addition of acetylcholine and by stimulation. Addition of acetylcholine had no effect on bursting activity, reduced spike activity strongly for a short period, after which activity increased again, but overall activity was reduced over time with 25%. After termination of acetylcholine addition the activity returned to normal.

    AB - The tegmental nucleus pedunculopontinus proves to connect by acetylcholine neurotransmitters, among others, the subthalamic nucleus. Dissociated cultures of the subthalamic nucleus on micro-electrode arrays were studied by addition of acetylcholine and by stimulation. Addition of acetylcholine had no effect on bursting activity, reduced spike activity strongly for a short period, after which activity increased again, but overall activity was reduced over time with 25%. After termination of acetylcholine addition the activity returned to normal.

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    Heida T, Marani E. Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. In XII Mediterranean Conference on Medical and Biological Engineering and Computing. Heidelberg: Springer. 2010. p. 180-183. (IFMBE Proceedings; 29). https://doi.org/10.1007/978-3-642-13039-7_45