Disulfide-containing poly (beta-amino ester)s for gene delivery

C. Lin, W.E. Hennink (Editor), T.M. Lammens, J. Feijen (Editor), Zhiyuan Zhong, T Sam (Editor), H. Gu, M.C. Lok, X. Jiang, Jan Feijen, Johannes F.J. Engbersen

Research output: Contribution to conferencePaperAcademic

1 Citation (Scopus)

Abstract

A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.
Original languageUndefined
Pages79-81
DOIs
Publication statusPublished - 5 Apr 2006
Event9th European Symposium on Controlled Drug Delivery, ESCDD 2006 - Noordwijk aan Zee, Netherlands
Duration: 5 Apr 20067 Apr 2006
Conference number: 9

Conference

Conference9th European Symposium on Controlled Drug Delivery, ESCDD 2006
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period5/04/067/04/06

Keywords

  • IR-71108
  • METIS-236897

Cite this

Lin, C., Hennink, W. E. (Ed.), Lammens, T. M., Feijen, J. (Ed.), Zhong, Z., Sam, T. (Ed.), ... Engbersen, J. F. J. (2006). Disulfide-containing poly (beta-amino ester)s for gene delivery. 79-81. Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2006.09.060
Lin, C. ; Hennink, W.E. (Editor) ; Lammens, T.M. ; Feijen, J. (Editor) ; Zhong, Zhiyuan ; Sam, T (Editor) ; Gu, H. ; Lok, M.C. ; Jiang, X. ; Feijen, Jan ; Engbersen, Johannes F.J. / Disulfide-containing poly (beta-amino ester)s for gene delivery. Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands.
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title = "Disulfide-containing poly (beta-amino ester)s for gene delivery",
abstract = "A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.",
keywords = "IR-71108, METIS-236897",
author = "C. Lin and W.E. Hennink and T.M. Lammens and J. Feijen and Zhiyuan Zhong and T Sam and H. Gu and M.C. Lok and X. Jiang and Jan Feijen and Engbersen, {Johannes F.J.}",
note = "Proceedings of the Ninth European Symposium on Controlled Drug Delivery ; null ; Conference date: 05-04-2006 Through 07-04-2006",
year = "2006",
month = "4",
day = "5",
doi = "10.1016/j.jconrel.2006.09.060",
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Lin, C, Hennink, WE (ed.), Lammens, TM, Feijen, J (ed.), Zhong, Z, Sam, T (ed.), Gu, H, Lok, MC, Jiang, X, Feijen, J & Engbersen, JFJ 2006, 'Disulfide-containing poly (beta-amino ester)s for gene delivery' Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands, 5/04/06 - 7/04/06, pp. 79-81. https://doi.org/10.1016/j.jconrel.2006.09.060

Disulfide-containing poly (beta-amino ester)s for gene delivery. / Lin, C.; Hennink, W.E. (Editor); Lammens, T.M.; Feijen, J. (Editor); Zhong, Zhiyuan; Sam, T (Editor); Gu, H.; Lok, M.C.; Jiang, X.; Feijen, Jan; Engbersen, Johannes F.J.

2006. 79-81 Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands.

Research output: Contribution to conferencePaperAcademic

TY - CONF

T1 - Disulfide-containing poly (beta-amino ester)s for gene delivery

AU - Lin, C.

AU - Lammens, T.M.

AU - Zhong, Zhiyuan

AU - Gu, H.

AU - Lok, M.C.

AU - Jiang, X.

AU - Feijen, Jan

AU - Engbersen, Johannes F.J.

A2 - Hennink, W.E.

A2 - Feijen, J.

A2 - Sam, T

N1 - Proceedings of the Ninth European Symposium on Controlled Drug Delivery

PY - 2006/4/5

Y1 - 2006/4/5

N2 - A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.

AB - A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.

KW - IR-71108

KW - METIS-236897

U2 - 10.1016/j.jconrel.2006.09.060

DO - 10.1016/j.jconrel.2006.09.060

M3 - Paper

SP - 79

EP - 81

ER -

Lin C, Hennink WE, (ed.), Lammens TM, Feijen J, (ed.), Zhong Z, Sam T, (ed.) et al. Disulfide-containing poly (beta-amino ester)s for gene delivery. 2006. Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2006.09.060