Disulfide-containing poly (beta-amino ester)s for gene delivery

C. Lin, W.E. Hennink (Editor), T.M. Lammens, J. Feijen (Editor), Zhiyuan Zhong, T Sam (Editor), H. Gu, M.C. Lok, X. Jiang, Jan Feijen, Johannes F.J. Engbersen

Research output: Contribution to conferencePaperAcademic

2 Citations (Scopus)

Abstract

A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.
Original languageUndefined
Pages79-81
DOIs
Publication statusPublished - 5 Apr 2006
Event9th European Symposium on Controlled Drug Delivery, ESCDD 2006 - Noordwijk aan Zee, Netherlands
Duration: 5 Apr 20067 Apr 2006
Conference number: 9

Conference

Conference9th European Symposium on Controlled Drug Delivery, ESCDD 2006
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period5/04/067/04/06

Keywords

  • IR-71108
  • METIS-236897

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