Disulfide-containing poly (beta-amino ester)s for gene delivery

C. Lin; W.E. Hennink; T.M. Lammens; J. Feijen; Zhiyuan Zhong; T Sam; H. Gu; M.C. Lok; X. Jiang; Jan Feijen; Johannes F.J. Engbersen

doi:10.1016/j.jconrel.2006.09.060

Disulfide-containing poly (beta-amino ester)s for gene delivery

C. Lin, W.E. Hennink (Editor), T.M. Lammens, J. Feijen (Editor), Zhiyuan Zhong, T Sam (Editor), H. Gu, M.C. Lok, X. Jiang, Jan Feijen, Johannes F.J. Engbersen

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Abstract

A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.

Original language	Undefined
Pages	79-81
DOIs	https://doi.org/10.1016/j.jconrel.2006.09.060
Publication status	Published - 5 Apr 2006
Event	9th European Symposium on Controlled Drug Delivery, ESCDD 2006 - Noordwijk aan Zee, Netherlands Duration: 5 Apr 2006 → 7 Apr 2006 Conference number: 9

Conference

Conference	9th European Symposium on Controlled Drug Delivery, ESCDD 2006
Abbreviated title	ESCDD
Country/Territory	Netherlands
City	Noordwijk aan Zee
Period	5/04/06 → 7/04/06

Keywords

IR-71108
METIS-236897

Access to Document

10.1016/j.jconrel.2006.09.060

Cite this

Lin, C., Hennink, W. E. (Ed.), Lammens, T. M., Feijen, J. (Ed.), Zhong, Z., Sam, T. (Ed.), Gu, H., Lok, M. C., Jiang, X., Feijen, J., & Engbersen, J. F. J. (2006). Disulfide-containing poly (beta-amino ester)s for gene delivery. 79-81. Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2006.09.060

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title = "Disulfide-containing poly (beta-amino ester)s for gene delivery",

abstract = "A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.",

keywords = "IR-71108, METIS-236897",

author = "C. Lin and W.E. Hennink and T.M. Lammens and J. Feijen and Zhiyuan Zhong and T Sam and H. Gu and M.C. Lok and X. Jiang and Jan Feijen and Engbersen, {Johannes F.J.}",

note = "Proceedings of the Ninth European Symposium on Controlled Drug Delivery ; 9th European Symposium on Controlled Drug Delivery, ESCDD 2006 ; Conference date: 05-04-2006 Through 07-04-2006",

year = "2006",

month = apr,

day = "5",

doi = "10.1016/j.jconrel.2006.09.060",

language = "Undefined",

pages = "79--81",

}

Lin, C, Hennink, WE (ed.), Lammens, TM, Feijen, J (ed.), Zhong, Z, Sam, T (ed.), Gu, H, Lok, MC, Jiang, X, Feijen, J & Engbersen, JFJ 2006, 'Disulfide-containing poly (beta-amino ester)s for gene delivery', Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands, 5/04/06 - 7/04/06 pp. 79-81. https://doi.org/10.1016/j.jconrel.2006.09.060

TY - CONF

T1 - Disulfide-containing poly (beta-amino ester)s for gene delivery

AU - Lin, C.

AU - Lammens, T.M.

AU - Zhong, Zhiyuan

AU - Gu, H.

AU - Lok, M.C.

AU - Jiang, X.

AU - Feijen, Jan

AU - Engbersen, Johannes F.J.

A2 - Hennink, W.E.

A2 - Feijen, J.

A2 - Sam, T

N1 - Conference code: 9

PY - 2006/4/5

Y1 - 2006/4/5

N2 - A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.

AB - A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.

KW - IR-71108

KW - METIS-236897

U2 - 10.1016/j.jconrel.2006.09.060

DO - 10.1016/j.jconrel.2006.09.060

M3 - Paper

SP - 79

EP - 81

T2 - 9th European Symposium on Controlled Drug Delivery, ESCDD 2006

Y2 - 5 April 2006 through 7 April 2006

ER -