A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.
|Publication status||Published - 5 Apr 2006|
|Event||9th European Symposium on Controlled Drug Delivery, ESCDD 2006 - Noordwijk aan Zee, Netherlands|
Duration: 5 Apr 2006 → 7 Apr 2006
Conference number: 9
|Conference||9th European Symposium on Controlled Drug Delivery, ESCDD 2006|
|City||Noordwijk aan Zee|
|Period||5/04/06 → 7/04/06|