Do external stimuli, applied to train cultured cortical networks, disturb the balance between activity and connectivity?

Jakob le Feber, J. Stegenga, Wim Rutten

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    Abstract

    Learning, or more generally, plasticity may be studied using cultured neuronal networks on multi electrode arrays. Many protocols have been proposed to change connectivity in such networks. So far, only one of these protocols, proposed by Shahaf and Marom, aimed to change the input-output relationship of a selected connection in the network. Although the results were quite promising, the experiments appeared difficult to repeat and the protocol did not serve as a basis for wider investigation yet. Here, we repeated their protocol, and compared our ‘learning curves’ to the original results. Although in some experiments the protocol did not seem to work, we found that on average, the protocol showed a significant learning effect indeed. We frequently found learning curves that initially declined as in the original results, but then increased again before finally settling at a low level.
    Original languageUndefined
    Title of host publicationProceedings of the 30th annual international IEEE EMBS conference
    Place of PublicationVancouver, BC
    PublisherIEEE
    Pages5081-5084
    Number of pages4
    ISBN (Print)978-1-4244-1814-5
    Publication statusPublished - Aug 2008
    Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2008 - Vancouver, Canada
    Duration: 20 Aug 200825 Aug 2008
    Conference number: 30

    Publication series

    Name
    PublisherIEEE

    Conference

    Conference30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2008
    Abbreviated titleEMBC
    CountryCanada
    CityVancouver
    Period20/08/0825/08/08

    Keywords

    • EWI-13383
    • METIS-252045
    • IR-60463
    • BSS-Neurotechnology and cellular engineering

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