Dopamine-based coatings and hydrogels: Toward substitution-related structure-property relationships

Jiaxi Cui, Jagoba Iturri, Julieta Paez, Zahid Shafiq, Cristina Serrano, Marco D'Ischia, Aránzazu Del Campo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

Abstract

The infl uence of 6-chloro and 6-nitro substituents on the thickness, homogeneity, and general properties of coatings produced by controlled oxidative polymerization of dopamine and its â-hydroxy derivative, norepinephrine, is investigated. Substitution at the catecholamine 6-position affects the deposition kinetics due to modifi cation of the oxidation potential of the catechol groups. Increasing the hydroxyl group acidity results likewise in changes in pH response and water uptake. A similar trend with pH is also observed in covalently crosslinked catechol-functionalized PEG-hydrogels, while an opposite behavior is measured in metal crosslinked fi lms. These results pave the way toward the defi nition of structure-property relationships based on dopamine substitution effects in polycatecholamine layers and derived polymers.

Original languageEnglish
Pages (from-to)2403-2413
Number of pages11
JournalMacromolecular chemistry and physics
Volume215
Issue number24
DOIs
Publication statusPublished - Dec 2014
Externally publishedYes

Keywords

  • DOPA
  • Dopamine coatings
  • Mussel adhesive protein
  • Polycatechols
  • n/a OA procedure

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