Dopamine-based coatings and hydrogels: Toward substitution-related structure-property relationships

Jiaxi Cui; Jagoba Iturri; Julieta Paez; Zahid Shafiq; Cristina Serrano; Marco D'Ischia; Aránzazu Del Campo

doi:10.1002/macp.201400366

Dopamine-based coatings and hydrogels: Toward substitution-related structure-property relationships

Jiaxi Cui, Jagoba Iturri, Julieta Paez, Zahid Shafiq, Cristina Serrano, Marco D'Ischia, Aránzazu Del Campo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

40 Citations (Scopus)

Abstract

The infl uence of 6-chloro and 6-nitro substituents on the thickness, homogeneity, and general properties of coatings produced by controlled oxidative polymerization of dopamine and its â-hydroxy derivative, norepinephrine, is investigated. Substitution at the catecholamine 6-position affects the deposition kinetics due to modifi cation of the oxidation potential of the catechol groups. Increasing the hydroxyl group acidity results likewise in changes in pH response and water uptake. A similar trend with pH is also observed in covalently crosslinked catechol-functionalized PEG-hydrogels, while an opposite behavior is measured in metal crosslinked fi lms. These results pave the way toward the defi nition of structure-property relationships based on dopamine substitution effects in polycatecholamine layers and derived polymers.

Original language	English
Pages (from-to)	2403-2413
Number of pages	11
Journal	Macromolecular chemistry and physics
Volume	215
Issue number	24
DOIs	https://doi.org/10.1002/macp.201400366
Publication status	Published - Dec 2014
Externally published	Yes

Keywords

DOPA
Dopamine coatings
Mussel adhesive protein
Polycatechols
n/a OA procedure

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10.1002/macp.201400366

Cite this

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title = "Dopamine-based coatings and hydrogels: Toward substitution-related structure-property relationships",

abstract = "The infl uence of 6-chloro and 6-nitro substituents on the thickness, homogeneity, and general properties of coatings produced by controlled oxidative polymerization of dopamine and its {\^a}-hydroxy derivative, norepinephrine, is investigated. Substitution at the catecholamine 6-position affects the deposition kinetics due to modifi cation of the oxidation potential of the catechol groups. Increasing the hydroxyl group acidity results likewise in changes in pH response and water uptake. A similar trend with pH is also observed in covalently crosslinked catechol-functionalized PEG-hydrogels, while an opposite behavior is measured in metal crosslinked fi lms. These results pave the way toward the defi nition of structure-property relationships based on dopamine substitution effects in polycatecholamine layers and derived polymers.",

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author = "Jiaxi Cui and Jagoba Iturri and Julieta Paez and Zahid Shafiq and Cristina Serrano and Marco D'Ischia and {Del Campo}, Ar{\'a}nzazu",

note = "Publisher Copyright: {\textcopyright} 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2014",

month = dec,

doi = "10.1002/macp.201400366",

language = "English",

volume = "215",

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T2 - Toward substitution-related structure-property relationships

AU - Cui, Jiaxi

AU - Iturri, Jagoba

AU - Paez, Julieta

AU - Shafiq, Zahid

AU - Serrano, Cristina

AU - D'Ischia, Marco

AU - Del Campo, Aránzazu

PY - 2014/12

Y1 - 2014/12

N2 - The infl uence of 6-chloro and 6-nitro substituents on the thickness, homogeneity, and general properties of coatings produced by controlled oxidative polymerization of dopamine and its â-hydroxy derivative, norepinephrine, is investigated. Substitution at the catecholamine 6-position affects the deposition kinetics due to modifi cation of the oxidation potential of the catechol groups. Increasing the hydroxyl group acidity results likewise in changes in pH response and water uptake. A similar trend with pH is also observed in covalently crosslinked catechol-functionalized PEG-hydrogels, while an opposite behavior is measured in metal crosslinked fi lms. These results pave the way toward the defi nition of structure-property relationships based on dopamine substitution effects in polycatecholamine layers and derived polymers.

AB - The infl uence of 6-chloro and 6-nitro substituents on the thickness, homogeneity, and general properties of coatings produced by controlled oxidative polymerization of dopamine and its â-hydroxy derivative, norepinephrine, is investigated. Substitution at the catecholamine 6-position affects the deposition kinetics due to modifi cation of the oxidation potential of the catechol groups. Increasing the hydroxyl group acidity results likewise in changes in pH response and water uptake. A similar trend with pH is also observed in covalently crosslinked catechol-functionalized PEG-hydrogels, while an opposite behavior is measured in metal crosslinked fi lms. These results pave the way toward the defi nition of structure-property relationships based on dopamine substitution effects in polycatecholamine layers and derived polymers.

KW - DOPA

KW - Dopamine coatings

KW - Mussel adhesive protein

KW - Polycatechols

KW - n/a OA procedure

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Dopamine-based coatings and hydrogels: Toward substitution-related structure-property relationships

Abstract

Keywords

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