Droplet encapsulation of electrokinetically-focused analytes without loss of resolution

Vasileios Papadimitriou*, Stella-Maria Annette Kruit, Loes Segerink, Jan C.T. Eijkel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Lab-on-chip electrokinetic focusing and separation techniques are widely used in several scientific fields. In a number of cases, these techniques have been combined with a selective analyte extraction for off-chip analysis. Nevertheless, the usability of the extracts is limited by diffusion which reduces the separation resolution. In this paper we propose the integration of a droplet generator capable of continuous or on-demand generation and extraction of electrokinetically separated and focused analytes. We demonstrate the selective droplet extraction of model analytes separated and concentrated via ion concentration polarization focusing (ICPF). We report extracted droplets with 1000-fold increased concentration. Importantly, the droplet generator does not interrupt the ICPF process making it suitable for integration with the majority of electrokinetic separation techniques.
Original languageEnglish
Pages (from-to)2209-2217
Number of pages9
JournalLab on a chip
Volume20
Issue number12
DOIs
Publication statusPublished - 15 May 2020

Keywords

  • UT-Hybrid-D

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