Droplet Manipulations in Two Phase Flow Microfluidics

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Abstract

Even though droplet microfluidics has been developed since the early 1980s, the number of applications that have resulted in commercial products is still relatively small. This is partly due to an ongoing maturation and integration of existing methods, but possibly also because of the emergence of new techniques, whose potential has not been fully realized. This review summarizes the currently existing techniques for manipulating droplets in two-phase flow microfluidics. Specifically, very recent developments like the use of acoustic waves, magnetic fields, surface energy wells, and electrostatic traps and rails are discussed. The physical principles are explained, and (potential) advantages and drawbacks of different methods in the sense of versatility, flexibility, tunability and durability are discussed, where possible, per technique and per droplet operation: generation, transport, sorting, coalescence and splitting.
Original languageEnglish
Pages (from-to)1768-1793
JournalMicromachines
Volume6
Issue number11
DOIs
Publication statusPublished - 13 Nov 2015

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Microfluidics
Two phase flow
Coalescence
Sorting
Interfacial energy
Rails
Electrostatics
Durability
Acoustic waves
Magnetic fields

Keywords

  • METIS-313219
  • IR-98140

Cite this

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title = "Droplet Manipulations in Two Phase Flow Microfluidics",
abstract = "Even though droplet microfluidics has been developed since the early 1980s, the number of applications that have resulted in commercial products is still relatively small. This is partly due to an ongoing maturation and integration of existing methods, but possibly also because of the emergence of new techniques, whose potential has not been fully realized. This review summarizes the currently existing techniques for manipulating droplets in two-phase flow microfluidics. Specifically, very recent developments like the use of acoustic waves, magnetic fields, surface energy wells, and electrostatic traps and rails are discussed. The physical principles are explained, and (potential) advantages and drawbacks of different methods in the sense of versatility, flexibility, tunability and durability are discussed, where possible, per technique and per droplet operation: generation, transport, sorting, coalescence and splitting.",
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Droplet Manipulations in Two Phase Flow Microfluidics. / Pit, Arjen; Duits, Michael H.G.; Mugele, Friedrich Gunther.

In: Micromachines, Vol. 6, No. 11, 13.11.2015, p. 1768-1793.

Research output: Contribution to journalArticleAcademicpeer-review

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