Droplet microfluidics to engineer smart building blocks for modular tissue engineering

Niels G.A. Willemen; Tom Kamperman; Cindy Kelder; Michelle Koerselman; João Crispim; Jan Hendriks; Sieger Henke; Xandra de Peuter; Piet Dijkstra; Marcel Karperien; Jeroen Leijten

Droplet microfluidics to engineer smart building blocks for modular tissue engineering

Niels G.A. Willemen, Tom Kamperman^*, Cindy Kelder, Michelle Koerselman, João Crispim, Jan Hendriks, Sieger Henke, Xandra de Peuter, Piet Dijkstra, Marcel Karperien, Jeroen Leijten

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Modular tissue engineering enables the formation of larger 3D multiscale tissues by assembly of building blocks composed of cells and/or (micro)materials. However, current tissue building blocks are static, thereby limiting the functionality of modular tissues. In this study, an advanced droplet microfluidics system is used to produce microgels that are optimized to act as smart tissue building blocks. The cell-sized microgels are functionalized with reactive moieties that allow for the microgels' in situ chemical and mechanical tuning, thereby providing spatiotemporal control over living modular tissues.

Original language	English
Title of host publication	MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	The Chemical and Biological Microsystems Society
Pages	721-722
Number of pages	2
ISBN (Electronic)	9781733419017
Publication status	Published - 2020
Event	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 - Virtual Event Duration: 4 Oct 2020 → 9 Oct 2020 Conference number: 24 https://microtas2020.org/

Conference

Conference	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020
Abbreviated title	MicroTAS 2020
City	Virtual Event
Period	4/10/20 → 9/10/20
Internet address	https://microtas2020.org/

Keywords

Biomaterials
Droplet generator
Microgels
Spatiotemporal control
Tissue engineering

Cite this

Willemen, N. G. A., Kamperman, T., Kelder, C., Koerselman, M., Crispim, J., Hendriks, J., Henke, S., de Peuter, X., Dijkstra, P., Karperien, M., & Leijten, J. (2020). Droplet microfluidics to engineer smart building blocks for modular tissue engineering. In MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 721-722). The Chemical and Biological Microsystems Society.

@inproceedings{ee68b917d592430089a85e8a5ca9bc02,

title = "Droplet microfluidics to engineer smart building blocks for modular tissue engineering",

abstract = "Modular tissue engineering enables the formation of larger 3D multiscale tissues by assembly of building blocks composed of cells and/or (micro)materials. However, current tissue building blocks are static, thereby limiting the functionality of modular tissues. In this study, an advanced droplet microfluidics system is used to produce microgels that are optimized to act as smart tissue building blocks. The cell-sized microgels are functionalized with reactive moieties that allow for the microgels' in situ chemical and mechanical tuning, thereby providing spatiotemporal control over living modular tissues.",

keywords = "Biomaterials, Droplet generator, Microgels, Spatiotemporal control, Tissue engineering",

author = "Willemen, {Niels G.A.} and Tom Kamperman and Cindy Kelder and Michelle Koerselman and Jo{\~a}o Crispim and Jan Hendriks and Sieger Henke and {de Peuter}, Xandra and Piet Dijkstra and Marcel Karperien and Jeroen Leijten",

year = "2020",

language = "English",

pages = "721--722",

booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "The Chemical and Biological Microsystems Society",

note = "24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",

url = "https://microtas2020.org/",

}

Willemen, NGA, Kamperman, T, Kelder, C, Koerselman, M, Crispim, J, Hendriks, J, Henke, S, de Peuter, X, Dijkstra, P, Karperien, M & Leijten, J 2020, Droplet microfluidics to engineer smart building blocks for modular tissue engineering. in MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, pp. 721-722, 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020, Virtual Event, 4/10/20.

Droplet microfluidics to engineer smart building blocks for modular tissue engineering. / Willemen, Niels G.A.; Kamperman, Tom; Kelder, Cindy et al.
MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, 2020. p. 721-722.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Droplet microfluidics to engineer smart building blocks for modular tissue engineering

AU - Willemen, Niels G.A.

AU - Kamperman, Tom

AU - Kelder, Cindy

AU - Koerselman, Michelle

AU - Crispim, João

AU - Hendriks, Jan

AU - Henke, Sieger

AU - de Peuter, Xandra

AU - Dijkstra, Piet

AU - Karperien, Marcel

AU - Leijten, Jeroen

N1 - Conference code: 24

PY - 2020

Y1 - 2020

N2 - Modular tissue engineering enables the formation of larger 3D multiscale tissues by assembly of building blocks composed of cells and/or (micro)materials. However, current tissue building blocks are static, thereby limiting the functionality of modular tissues. In this study, an advanced droplet microfluidics system is used to produce microgels that are optimized to act as smart tissue building blocks. The cell-sized microgels are functionalized with reactive moieties that allow for the microgels' in situ chemical and mechanical tuning, thereby providing spatiotemporal control over living modular tissues.

AB - Modular tissue engineering enables the formation of larger 3D multiscale tissues by assembly of building blocks composed of cells and/or (micro)materials. However, current tissue building blocks are static, thereby limiting the functionality of modular tissues. In this study, an advanced droplet microfluidics system is used to produce microgels that are optimized to act as smart tissue building blocks. The cell-sized microgels are functionalized with reactive moieties that allow for the microgels' in situ chemical and mechanical tuning, thereby providing spatiotemporal control over living modular tissues.

KW - Biomaterials

KW - Droplet generator

KW - Microgels

KW - Spatiotemporal control

KW - Tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=85098262588&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85098262588

SP - 721

EP - 722

BT - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - The Chemical and Biological Microsystems Society

T2 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020

Y2 - 4 October 2020 through 9 October 2020

ER -

Droplet microfluidics to engineer smart building blocks for modular tissue engineering

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Keywords

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