Droplet microfluidics to engineer smart building blocks for modular tissue engineering

Niels Willemen, Tom Kamperman*, Cindy Kelder, Michelle Koerselman, João Crispim, Jan Hendriks, Sieger Henke, Xandra de Peuter, Piet Dijkstra, Marcel Karperien, Jeroen Leijten

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Modular tissue engineering enables the formation of larger 3D multiscale tissues by assembly of building blocks composed of cells and/or (micro)materials. However, current tissue building blocks are static, thereby limiting the functionality of modular tissues. In this study, an advanced droplet microfluidics system is used to produce microgels that are optimized to act as smart tissue building blocks. The cell-sized microgels are functionalized with reactive moieties that allow for the microgels' in situ chemical and mechanical tuning, thereby providing spatiotemporal control over living modular tissues.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherThe Chemical and Biological Microsystems Society
Pages721-722
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 - Virtual Event
Duration: 4 Oct 20209 Oct 2020
Conference number: 24
https://microtas2020.org/

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020
Abbreviated titleMicroTAS 2020
CityVirtual Event
Period4/10/209/10/20
Internet address

Keywords

  • Biomaterials
  • Droplet generator
  • Microgels
  • Spatiotemporal control
  • Tissue engineering

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