Droplets, Bubbles and Ultrasound Interactions

O. Shpak, M. Verweij, N. de Jong, Michel Versluis

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

13 Citations (Scopus)

Abstract

The interaction of droplets and bubbles with ultrasound has been studied extensively in the last 25 years. Microbubbles are broadly used in diagnostic and therapeutic medical applications, for instance, as ultrasound contrast agents. They have a similar size as red blood cells, and thus are able to circulate within blood vessels. Perfluorocarbon liquid droplets can be a potential new generation of microbubble agents as ultrasound can trigger their conversion into gas bubbles. Prior to activation, they are at least five times smaller in diameter than the resulting bubbles. Together with the violent nature of the phase-transition, the droplets can be used for local drug delivery, embolotherapy, HIFU enhancement and tumor imaging. Here we explain the basics of bubble dynamics, described by the Rayleigh-Plesset equation, bubble resonance frequency, damping and quality factor. We show the elegant calculation of the above characteristics for the case of small amplitude oscillations by linearizing the equations. The effect and importance of a bubble coating and effective surface tension are also discussed. We give the main characteristics of the power spectrum of bubble oscillations. Preceding bubble dynamics, ultrasound propagation is introduced. We explain the speed of sound, nonlinearity and attenuation terms. We examine bubble ultrasound scattering and how it depends on the wave-shape of the incident wave. Finally, we introduce droplet interaction with ultrasound. We elucidate the ultrasound-focusing concept within a droplets sphere, droplet shaking due to media compressibility and droplet phase-conversion dynamics.
Original languageEnglish
Title of host publicationTherapeutic Ultrasound: From biophysics concepts to clinical applications
EditorsJ.M. Escoffre, A. Bouakaz
PublisherSpringer
Pages157-174
Number of pages18
ISBN (Print)978-3-319-22535-7
DOIs
Publication statusPublished - 2016

Publication series

NameAdvances in experimental medicine and biology
PublisherSpringer International Publishing
Number880

Fingerprint

bubbles
interactions
Rayleigh equations
oscillations
shaking
blood vessels
erythrocytes
compressibility
power spectra
Q factors
delivery
interfacial tension
drugs
tumors
actuators
damping
attenuation
nonlinearity
activation
coatings

Keywords

  • METIS-315171
  • IR-99588

Cite this

Shpak, O., Verweij, M., de Jong, N., & Versluis, M. (2016). Droplets, Bubbles and Ultrasound Interactions. In J. M. Escoffre, & A. Bouakaz (Eds.), Therapeutic Ultrasound: From biophysics concepts to clinical applications (pp. 157-174). (Advances in experimental medicine and biology; No. 880). Springer. https://doi.org/10.1007/978-3-319-22536-4_9
Shpak, O. ; Verweij, M. ; de Jong, N. ; Versluis, Michel. / Droplets, Bubbles and Ultrasound Interactions. Therapeutic Ultrasound: From biophysics concepts to clinical applications. editor / J.M. Escoffre ; A. Bouakaz. Springer, 2016. pp. 157-174 (Advances in experimental medicine and biology; 880).
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Shpak, O, Verweij, M, de Jong, N & Versluis, M 2016, Droplets, Bubbles and Ultrasound Interactions. in JM Escoffre & A Bouakaz (eds), Therapeutic Ultrasound: From biophysics concepts to clinical applications. Advances in experimental medicine and biology, no. 880, Springer, pp. 157-174. https://doi.org/10.1007/978-3-319-22536-4_9

Droplets, Bubbles and Ultrasound Interactions. / Shpak, O.; Verweij, M.; de Jong, N.; Versluis, Michel.

Therapeutic Ultrasound: From biophysics concepts to clinical applications. ed. / J.M. Escoffre; A. Bouakaz. Springer, 2016. p. 157-174 (Advances in experimental medicine and biology; No. 880).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

TY - CHAP

T1 - Droplets, Bubbles and Ultrasound Interactions

AU - Shpak, O.

AU - Verweij, M.

AU - de Jong, N.

AU - Versluis, Michel

PY - 2016

Y1 - 2016

N2 - The interaction of droplets and bubbles with ultrasound has been studied extensively in the last 25 years. Microbubbles are broadly used in diagnostic and therapeutic medical applications, for instance, as ultrasound contrast agents. They have a similar size as red blood cells, and thus are able to circulate within blood vessels. Perfluorocarbon liquid droplets can be a potential new generation of microbubble agents as ultrasound can trigger their conversion into gas bubbles. Prior to activation, they are at least five times smaller in diameter than the resulting bubbles. Together with the violent nature of the phase-transition, the droplets can be used for local drug delivery, embolotherapy, HIFU enhancement and tumor imaging. Here we explain the basics of bubble dynamics, described by the Rayleigh-Plesset equation, bubble resonance frequency, damping and quality factor. We show the elegant calculation of the above characteristics for the case of small amplitude oscillations by linearizing the equations. The effect and importance of a bubble coating and effective surface tension are also discussed. We give the main characteristics of the power spectrum of bubble oscillations. Preceding bubble dynamics, ultrasound propagation is introduced. We explain the speed of sound, nonlinearity and attenuation terms. We examine bubble ultrasound scattering and how it depends on the wave-shape of the incident wave. Finally, we introduce droplet interaction with ultrasound. We elucidate the ultrasound-focusing concept within a droplets sphere, droplet shaking due to media compressibility and droplet phase-conversion dynamics.

AB - The interaction of droplets and bubbles with ultrasound has been studied extensively in the last 25 years. Microbubbles are broadly used in diagnostic and therapeutic medical applications, for instance, as ultrasound contrast agents. They have a similar size as red blood cells, and thus are able to circulate within blood vessels. Perfluorocarbon liquid droplets can be a potential new generation of microbubble agents as ultrasound can trigger their conversion into gas bubbles. Prior to activation, they are at least five times smaller in diameter than the resulting bubbles. Together with the violent nature of the phase-transition, the droplets can be used for local drug delivery, embolotherapy, HIFU enhancement and tumor imaging. Here we explain the basics of bubble dynamics, described by the Rayleigh-Plesset equation, bubble resonance frequency, damping and quality factor. We show the elegant calculation of the above characteristics for the case of small amplitude oscillations by linearizing the equations. The effect and importance of a bubble coating and effective surface tension are also discussed. We give the main characteristics of the power spectrum of bubble oscillations. Preceding bubble dynamics, ultrasound propagation is introduced. We explain the speed of sound, nonlinearity and attenuation terms. We examine bubble ultrasound scattering and how it depends on the wave-shape of the incident wave. Finally, we introduce droplet interaction with ultrasound. We elucidate the ultrasound-focusing concept within a droplets sphere, droplet shaking due to media compressibility and droplet phase-conversion dynamics.

KW - METIS-315171

KW - IR-99588

U2 - 10.1007/978-3-319-22536-4_9

DO - 10.1007/978-3-319-22536-4_9

M3 - Chapter

SN - 978-3-319-22535-7

T3 - Advances in experimental medicine and biology

SP - 157

EP - 174

BT - Therapeutic Ultrasound: From biophysics concepts to clinical applications

A2 - Escoffre, J.M.

A2 - Bouakaz, A.

PB - Springer

ER -

Shpak O, Verweij M, de Jong N, Versluis M. Droplets, Bubbles and Ultrasound Interactions. In Escoffre JM, Bouakaz A, editors, Therapeutic Ultrasound: From biophysics concepts to clinical applications. Springer. 2016. p. 157-174. (Advances in experimental medicine and biology; 880). https://doi.org/10.1007/978-3-319-22536-4_9