Dual stimuli-responsive self-assembled supramolecular nanoparticles

C. Stoffelen, Jens Voskuhl, Pascal Jonkheijm, Jurriaan Huskens

Research output: Contribution to journalArticleAcademicpeer-review

94 Citations (Scopus)

Abstract

Supramolecular nanoparticles (SNPs) encompass multiple copies of different building blocks brought together by specific noncovalent interactions. The inherently multivalent nature of these systems allows control of their size as well as their assembly and disassembly, thus promising potential as biomedical delivery vehicles. Here, dual responsive SNPs have been based on the ternary host–guest complexation between cucurbit[8]uril (CB[8]), a methyl viologen (MV) polymer, and mono- and multivalent azobenzene (Azo) functionalized molecules. UV switching of the Azo groups led to fast disruption of the ternary complexes, but to a relatively slow disintegration of the SNPs. Alternating UV and Vis photoisomerization of the Azo groups led to fully reversible SNP disassembly and reassembly. SNPs were only formed with the Azo moieties in the trans and the MV units in the oxidized states, respectively, thus constituting a supramolecular AND logic gate.
Original languageUndefined
Pages (from-to)3400-3404
Number of pages5
JournalAngewandte Chemie (international edition)
Volume53
Issue number13
DOIs
Publication statusPublished - 2014

Keywords

  • IR-95099
  • METIS-308507

Cite this

Stoffelen, C. ; Voskuhl, Jens ; Jonkheijm, Pascal ; Huskens, Jurriaan. / Dual stimuli-responsive self-assembled supramolecular nanoparticles. In: Angewandte Chemie (international edition). 2014 ; Vol. 53, No. 13. pp. 3400-3404.
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Dual stimuli-responsive self-assembled supramolecular nanoparticles. / Stoffelen, C.; Voskuhl, Jens; Jonkheijm, Pascal; Huskens, Jurriaan.

In: Angewandte Chemie (international edition), Vol. 53, No. 13, 2014, p. 3400-3404.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Dual stimuli-responsive self-assembled supramolecular nanoparticles

AU - Stoffelen, C.

AU - Voskuhl, Jens

AU - Jonkheijm, Pascal

AU - Huskens, Jurriaan

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N2 - Supramolecular nanoparticles (SNPs) encompass multiple copies of different building blocks brought together by specific noncovalent interactions. The inherently multivalent nature of these systems allows control of their size as well as their assembly and disassembly, thus promising potential as biomedical delivery vehicles. Here, dual responsive SNPs have been based on the ternary host–guest complexation between cucurbit[8]uril (CB[8]), a methyl viologen (MV) polymer, and mono- and multivalent azobenzene (Azo) functionalized molecules. UV switching of the Azo groups led to fast disruption of the ternary complexes, but to a relatively slow disintegration of the SNPs. Alternating UV and Vis photoisomerization of the Azo groups led to fully reversible SNP disassembly and reassembly. SNPs were only formed with the Azo moieties in the trans and the MV units in the oxidized states, respectively, thus constituting a supramolecular AND logic gate.

AB - Supramolecular nanoparticles (SNPs) encompass multiple copies of different building blocks brought together by specific noncovalent interactions. The inherently multivalent nature of these systems allows control of their size as well as their assembly and disassembly, thus promising potential as biomedical delivery vehicles. Here, dual responsive SNPs have been based on the ternary host–guest complexation between cucurbit[8]uril (CB[8]), a methyl viologen (MV) polymer, and mono- and multivalent azobenzene (Azo) functionalized molecules. UV switching of the Azo groups led to fast disruption of the ternary complexes, but to a relatively slow disintegration of the SNPs. Alternating UV and Vis photoisomerization of the Azo groups led to fully reversible SNP disassembly and reassembly. SNPs were only formed with the Azo moieties in the trans and the MV units in the oxidized states, respectively, thus constituting a supramolecular AND logic gate.

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