Abstract
This article describes two different types of dynamic combinatorial libraries of host and guest molecules. The first part of this article describes the encapsulation of alizarin trimer 2 a3 by dynamic mixtures of up to twenty different self-assembled molecular receptors together with the amplification and selection of the best binder. Receptors (1 a-d)3(DEB)6 are formed by the self-assembly of six diethyl barbiturate (DEB) and calix[4]arene dimelamine derivatives 1 a-d by using hydrogen bonds. The largest amplification factor (2.8) for a host assembly (1 a3 (DEB)6) was observed after the addition of 2 a to four-component library 1 an1 b(3-n)(DEB)6 (n=0-3). Addition of 2 a to twenty-component library 1 an1 bm1 co1 d(3-(n+m+o))(DEB)6 (n, m, o=0-3; (n+m+o)3) also showed amplification of receptor 1 a3(DEB)6. The second part of this article describes the complexation of libraries of different alizarin-like guest molecules (2 a-d) and the self-assembled receptor 1 a3(DEB)6. This receptor is able to template the formation of the best-fitting guest trimer.
Original language | Undefined |
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Pages (from-to) | 2377-2385 |
Number of pages | 9 |
Journal | Chemistry : a European journal |
Volume | 13 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2007 |
Keywords
- Binding selectivity
- Hydrogen bonds
- Self-Assembly
- combinatorial chemistry
- molecular capsules
- METIS-241413
- IR-72332