Abstract
| Original language | Undefined |
|---|---|
| Pages (from-to) | 2377-2385 |
| Number of pages | 9 |
| Journal | Chemistry: a European journal |
| Volume | 13 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2007 |
Keywords
- Binding selectivity
- Hydrogen bonds
- Self-Assembly
- combinatorial chemistry
- molecular capsules
- METIS-241413
- IR-72332
Cite this
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Dynamic combinatorial libraries based on hydrogen-bonde molecular boxes. / Kerckhoffs, J.M.C.A.; Mateos timoneda, Miguel; Reinhoudt, David; Crego Calama, Mercedes.
In: Chemistry: a European journal, Vol. 13, No. 8, 2007, p. 2377-2385.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Dynamic combinatorial libraries based on hydrogen-bonde molecular boxes
AU - Kerckhoffs, J.M.C.A.
AU - Mateos timoneda, Miguel
AU - Reinhoudt, David
AU - Crego Calama, Mercedes
PY - 2007
Y1 - 2007
N2 - This article describes two different types of dynamic combinatorial libraries of host and guest molecules. The first part of this article describes the encapsulation of alizarin trimer 2 a3 by dynamic mixtures of up to twenty different self-assembled molecular receptors together with the amplification and selection of the best binder. Receptors (1 a-d)3(DEB)6 are formed by the self-assembly of six diethyl barbiturate (DEB) and calix[4]arene dimelamine derivatives 1 a-d by using hydrogen bonds. The largest amplification factor (2.8) for a host assembly (1 a3 (DEB)6) was observed after the addition of 2 a to four-component library 1 an1 b(3-n)(DEB)6 (n=0-3). Addition of 2 a to twenty-component library 1 an1 bm1 co1 d(3-(n+m+o))(DEB)6 (n, m, o=0-3; (n+m+o)3) also showed amplification of receptor 1 a3(DEB)6. The second part of this article describes the complexation of libraries of different alizarin-like guest molecules (2 a-d) and the self-assembled receptor 1 a3(DEB)6. This receptor is able to template the formation of the best-fitting guest trimer.
AB - This article describes two different types of dynamic combinatorial libraries of host and guest molecules. The first part of this article describes the encapsulation of alizarin trimer 2 a3 by dynamic mixtures of up to twenty different self-assembled molecular receptors together with the amplification and selection of the best binder. Receptors (1 a-d)3(DEB)6 are formed by the self-assembly of six diethyl barbiturate (DEB) and calix[4]arene dimelamine derivatives 1 a-d by using hydrogen bonds. The largest amplification factor (2.8) for a host assembly (1 a3 (DEB)6) was observed after the addition of 2 a to four-component library 1 an1 b(3-n)(DEB)6 (n=0-3). Addition of 2 a to twenty-component library 1 an1 bm1 co1 d(3-(n+m+o))(DEB)6 (n, m, o=0-3; (n+m+o)3) also showed amplification of receptor 1 a3(DEB)6. The second part of this article describes the complexation of libraries of different alizarin-like guest molecules (2 a-d) and the self-assembled receptor 1 a3(DEB)6. This receptor is able to template the formation of the best-fitting guest trimer.
KW - Binding selectivity
KW - Hydrogen bonds
KW - Self-Assembly
KW - combinatorial chemistry
KW - molecular capsules
KW - METIS-241413
KW - IR-72332
U2 - 10.1002/chem.200601198
DO - 10.1002/chem.200601198
M3 - Article
VL - 13
SP - 2377
EP - 2385
JO - Chemistry: a European journal
JF - Chemistry: a European journal
SN - 0947-6539
IS - 8
ER -