Early clinical experience with the implantation of a novel synthetic coronary stent graft

Clemens Von Birgelen* (Corresponding Author), Michael Haude, Jörg Herrmann, Christoph Altmann, Wolfgang Klinkhart, Dirk Welge, Heinrich Wieneke, Dietrich Baumgart, Stefan Sack, Raimund Erbel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)


Coating stents with autologous venous grafts has been suggested to prevent problems associated with conventional stenting, but the need for surgical vessel harvest hampered broad application. A novel synthetic coronary stent graft (CSG) overcomes this limitation by a synthetic membrane, fixed between two thin metallic stents. We successfully implanted 21 CSGs in 18 patients for treatment of acute coronary rupture, thrombus-containing lesions, and lesions with plaque rupture or adjacent pseudoaneurysm. Substantial residual angiographic diameter stenoses were seen in seven CSGs (25% ± 10% vs. 8% ± 6%; P < 0.01), which were implanted with relatively small balloon catheters (balloon-to-artery ratio 1.00 ± 0.09 vs. 1.24 ± 0.18; P= 0.01) and required postdilatation. Overall, the largest balloon catheter applied measured 4.0 ± 0.7 mm (balloon-to-artery ratio 1.21 ± 0.20) and the inflation pressure was 16 ± 3 atm. Final intravascular ultrasound imaging demonstrated adequate and symmetrical expansion of the CSG (≥85% ± 15% of the reference lumen). Elective implantation was associated with two small non-Q-wave myocardial infarctions, resulting from unavoidable occlusions of side branches. Thus, implantation of CSG is feasible and safe. Adequate expansion can be achieved by the use of relatively large low- compliant balloon catheters inflated with high pressure.

Original languageEnglish
Pages (from-to)496-503
Number of pages8
JournalCatheterization and cardiovascular interventions
Issue number4
Publication statusPublished - 1 Aug 1999
Externally publishedYes


  • Coated stent
  • Coronary angioplasty
  • Coronary stent
  • Coronary stent graft
  • Covered stent
  • Intravascular ultrasound


Dive into the research topics of 'Early clinical experience with the implantation of a novel synthetic coronary stent graft'. Together they form a unique fingerprint.

Cite this