EEG in postanoxic coma: Prognostic and diagnostic value

J. Hofmeijer*, M.J.A.M. van Putten

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

80 Citations (Scopus)
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Evolution of the EEG background pattern is a robust contributor to prediction of poor or good outcome of comatose patients after cardiac arrest. At 24 h, persistent isoelectricity, low voltage activity, or burst-suppression with identical bursts predicts a poor outcome without false positives. Rapid recovery toward continuous patterns within 12 h is strongly associated with a good neurological outcome. Predictive values are highest in the first 24 h, despite the use of mild therapeutic hypothermia and sedative medication. Studies on reactivity or mismatch negativity have not included the EEG background pattern. Therefore, the additional predictive value of reactivity parameters remains unclear. Whether or not treatment of electrographic status epilepticus improves outcome is studied in the randomized multicenter Treatment of Electroencephalographic STatus epilepticus After cardiopulmonary Resuscitation (TELSTAR) trial (NCT02056236).
Original languageEnglish
Pages (from-to)2047-2055
Number of pages9
JournalClinical neurophysiology
Issue number4
Publication statusPublished - 2016


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