Abstract
Ghrelin is a gastric hormone and a neuropeptide, initially related to the appetite stimulation and growth hormone secretation. Ghrelin has also an important role in regulation of many other processes, including higher brain funtions like memory performance, sleep and wakefulness. Previous studies on the ghrelin activities indicate that the transmitter has an excitatory effect on the neuronal activity of hypothalamic slices in vitro by direct synaptic interaction, and controls synaptic plasticity in the hippocampus when applied intravenously. However the effect of ghrelin on developing neuronal networks has not been studied yet. Therefore we cultured dissociated cortical neurons of newborn rats in a medium containing ghrelin for a period of three weeks and recorded the network activity using multy electrod arrays,.
Original language | Undefined |
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Title of host publication | Proceedings MEA Meeting 2010 |
Editors | A Stett |
Place of Publication | Stuttgart, Germany |
Publisher | BIOPRO Baden- Wurttemberg GmbH |
Pages | 30-33 |
Number of pages | 4 |
ISBN (Print) | 978-3-938345-08-5 |
Publication status | Published - 29 Jun 2010 |
Event | 7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010 - Reutlingen, Germany Duration: 29 Jun 2010 → 2 Jul 2010 Conference number: 7 |
Publication series
Name | NMI achieving results |
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Publisher | BIOPRO Baden- Wurttemberg GmbH |
Conference
Conference | 7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010 |
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Abbreviated title | MEA |
Country/Territory | Germany |
City | Reutlingen |
Period | 29/06/10 → 2/07/10 |
Keywords
- METIS-270899
- IR-72299
- neuronal activity
- BSS-Neurotechnology and cellular engineering
- EWI-18106
- hypothalamic slices in vitro
- Effect of ghrelin