Effect of ghrelin on the network development and activity in cultured cortical neurons of newborn rats

Irina Stoyanova, Jakob le Feber, Wim Rutten

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    Ghrelin is a gastric hormone and a neuropeptide, initially related to the appetite stimulation and growth hormone secretation. Ghrelin has also an important role in regulation of many other processes, including higher brain funtions like memory performance, sleep and wakefulness. Previous studies on the ghrelin activities indicate that the transmitter has an excitatory effect on the neuronal activity of hypothalamic slices in vitro by direct synaptic interaction, and controls synaptic plasticity in the hippocampus when applied intravenously. However the effect of ghrelin on developing neuronal networks has not been studied yet. Therefore we cultured dissociated cortical neurons of newborn rats in a medium containing ghrelin for a period of three weeks and recorded the network activity using multy electrod arrays,.
    Original languageUndefined
    Title of host publicationProceedings MEA Meeting 2010
    EditorsA Stett
    Place of PublicationStuttgart, Germany
    PublisherBIOPRO Baden- Wurttemberg GmbH
    Number of pages4
    ISBN (Print)978-3-938345-08-5
    Publication statusPublished - 29 Jun 2010
    Event7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010 - Reutlingen, Germany
    Duration: 29 Jun 20102 Jul 2010
    Conference number: 7

    Publication series

    NameNMI achieving results
    PublisherBIOPRO Baden- Wurttemberg GmbH


    Conference7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010
    Abbreviated titleMEA


    • METIS-270899
    • IR-72299
    • neuronal activity
    • BSS-Neurotechnology and cellular engineering
    • EWI-18106
    • hypothalamic slices in vitro
    • Effect of ghrelin

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