Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging

Vinayakrishnan Rajan, Babu Varghese, Ton van Leeuwen, Wiendelt Steenbergen

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Abstract

A theoretical model is presented and experimentally validated that allows the prediction of the effect of speckles on the depth sensitivity of laser Doppler perfusion imaging. It is shown that the influence of speckles on depth sensitivity is large. In particular the sensitivity to particle motion in superficial layers is strongly beam diameter dependent: decreasing the beam diameter on the tissue surface increases the sensitivity to superficial motion to a much stronger extent than sensitivity to motion at a larger depth. This can be explained through the effect of beam diameter changes on the fractional coherence areas generated by photons with different penetration depths in the tissue.
Original languageEnglish
Pages (from-to)10911-10919
Number of pages9
JournalOptics express
Volume15
Issue number17
DOIs
Publication statusPublished - 2007

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lasers
sensitivity
particle motion
penetration
photons
predictions

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Rajan, Vinayakrishnan ; Varghese, Babu ; van Leeuwen, Ton ; Steenbergen, Wiendelt. / Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging. In: Optics express. 2007 ; Vol. 15, No. 17. pp. 10911-10919.
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Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging. / Rajan, Vinayakrishnan; Varghese, Babu; van Leeuwen, Ton; Steenbergen, Wiendelt.

In: Optics express, Vol. 15, No. 17, 2007, p. 10911-10919.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging

AU - Rajan, Vinayakrishnan

AU - Varghese, Babu

AU - van Leeuwen, Ton

AU - Steenbergen, Wiendelt

PY - 2007

Y1 - 2007

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AB - A theoretical model is presented and experimentally validated that allows the prediction of the effect of speckles on the depth sensitivity of laser Doppler perfusion imaging. It is shown that the influence of speckles on depth sensitivity is large. In particular the sensitivity to particle motion in superficial layers is strongly beam diameter dependent: decreasing the beam diameter on the tissue surface increases the sensitivity to superficial motion to a much stronger extent than sensitivity to motion at a larger depth. This can be explained through the effect of beam diameter changes on the fractional coherence areas generated by photons with different penetration depths in the tissue.

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DO - 10.1364/OE.15.010911

M3 - Article

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JO - Optics express

JF - Optics express

SN - 1094-4087

IS - 17

ER -