TY - JOUR
T1 - Effect of surface morphology of poly(ïμ-caprolactone) scaffolds on adipose stem cell adhesion and proliferation
AU - Diban-Ibrahim Gomez, Nazely
AU - Haimi, Suvi
AU - Bolhuis-Versteeg, Lydia A.M.
AU - Da Silva Teixeira, Sandra
AU - Miettinen, S.
AU - Poot, Andreas A.
AU - Grijpma, Dirk W.
AU - Stamatialis, Dimitrios
N1 - Special Issue: Advanced Functional Polymers in Medicine
PY - 2013
Y1 - 2013
N2 - The effect of the surface morphology of flat poly(ϵ-caprolactone) (PCL) scaffolds on human adipose stem cell (hASC) adherence and proliferation was studied. During fabrication of the scaffolds by phase inversion, the employment of different non-solvents (water (W), ethanol (EtOH) or isopropanol (IPA)) led to distinct surface morphologies. It was found that PCL scaffolds fabricated using IPA as a non-solvent had a higher roughness and porosity compared to the other groups. Moreover, during culturing of hASCs under static conditions, best cell attachment, spreading and growth were observed on the PCL scaffold. Our results show the potential of PCL scaffolds prepared using IPA as a non-solvent for especially soft tissue engineering applications.
AB - The effect of the surface morphology of flat poly(ϵ-caprolactone) (PCL) scaffolds on human adipose stem cell (hASC) adherence and proliferation was studied. During fabrication of the scaffolds by phase inversion, the employment of different non-solvents (water (W), ethanol (EtOH) or isopropanol (IPA)) led to distinct surface morphologies. It was found that PCL scaffolds fabricated using IPA as a non-solvent had a higher roughness and porosity compared to the other groups. Moreover, during culturing of hASCs under static conditions, best cell attachment, spreading and growth were observed on the PCL scaffold. Our results show the potential of PCL scaffolds prepared using IPA as a non-solvent for especially soft tissue engineering applications.
KW - METIS-300411
KW - IR-90081
U2 - 10.1002/masy.201300106
DO - 10.1002/masy.201300106
M3 - Article
SN - 1022-1360
VL - 334
SP - 126
EP - 132
JO - Macromolecular symposia
JF - Macromolecular symposia
IS - 1
T2 - 533th WE-Heraeus-Seminar "Advanced Functional Polymers in Medicine" 2013
Y2 - 27 May 2013 through 29 May 2013
ER -