Effects of charge density and hydrophobicity: acetylation versus benzolation of amino butyl SS-PAAS for gene delivery

Martin Piest, Johan F.J. Engbersen

    Research output: Contribution to journalMeeting AbstractAcademic

    4 Citations (Scopus)

    Abstract

    High densities of positive charge in polymeric vectors not only result in efficient DNA condensation and particle uptake, but also induce membrane disruption, generally resulting in undesired high cytotoxicity. We previously developed a class of bioreducible poly(amido amine)s (SS-PAA)s that are significantly less toxic than PEI. In this paper we report the effect of different degrees of acetylation or benzoylation of pendant butylamine side groups in an SS-PAA. It was found that the introduction of the lipophilic benzoyl group results in a higher transfection efficiency.
    Original languageEnglish
    Pages (from-to)e92-e94
    JournalJournal of controlled release
    Volume148
    Issue number1
    DOIs
    Publication statusPublished - 7 Apr 2010
    Event11th European Symposium on Controlled Drug Delivery, ESCDD 2010 - Hotel Zuiderduin, Egmond aan Zee (NL), Netherlands
    Duration: 7 Apr 20109 Apr 2010
    Conference number: 11

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