High densities of positive charge in polymeric vectors not only result in efficient DNA condensation and particle uptake, but also induce membrane disruption, generally resulting in undesired high cytotoxicity. We previously developed a class of bioreducible poly(amido amine)s (SS-PAA)s that are significantly less toxic than PEI. In this paper we report the effect of different degrees of acetylation or benzoylation of pendant butylamine side groups in an SS-PAA. It was found that the introduction of the lipophilic benzoyl group results in a higher transfection efficiency.
|Journal||Journal of controlled release|
|Publication status||Published - 7 Apr 2010|
|Event||11th European Symposium on Controlled Drug Delivery, ESCDD 2010 - Hotel Zuiderduin, Egmond aan Zee (NL), Netherlands|
Duration: 7 Apr 2010 → 9 Apr 2010
Conference number: 11