Effects of expectation on Somatosensory Event-related Potentials (SEPs) elicited by painful electric stimuli

M.A. Jongsma, C.M. van Rijn, E. van den Broeke, S. Postma, R. van der Lubbe, J.R. Buitenweg, M. Arns, R. Quian Quiroga, H. van Goor, M. Luckers, O.H.G. Wilder-Smith

Research output: Contribution to journalMeeting AbstractAcademic

Abstract

Background and Aims: Pain perception is typically measured by questionnaires and behavioural responses. Somatosensory Evoked Potentials (SEPs) however provide a direct measure of stimulus processing in the brain. To investigate whether expectancy influences SEPs we applied a cross‐modal oddball paradigm. The P3 EP component is modulated by expectancy, anticipation and novelty. We hypothesize that the number of background stimuli preceding the painful target determines the expectancy of the target and consequently the amplitude of the P3.

Methods: A multi‐channel EEG was recorded (band pass 0.1–100 Hz, sample frequency 1000Hz) from 11 volunteers. Trials commenced with 3, to 11 auditory stimuli, followed by a painful electric target stimulus (ring finger, 1ms duration, individually set to a subjective pain intensity level of 9; 0 = no pain; 10 = maximum pain). Inter‐stimulus intervals were 800 ms. After target presentation the participants rated the stimulus painfulness (0–9).

Results and Discussion: An increase in the number of auditory background stimuli preceding the painful stimulus was accompanied with a larger lateralised N130, possibly due to an increase in attention. The centrally localized P350 decreased, as hypothesized, as did the late N450. SEP changes were observed up to 7 preceding background stimuli, after which the effect levelled off. No effects of number of backgrounds was found with respect to the perceived intensity. We propose that SEP P350 components elicited by oddball paradigm behave similarly to P3 EP components observed in other modalities. It will be interesting to study whether cognitive SEP modulation differs between chronic pain patients and healthy volunteers.
Original languageEnglish
Article number263
Pages (from-to)S71-S71
JournalPain
Volume10
Issue number1
DOIs
Publication statusPublished - 2006
EventPain in Europe V 2006 - Istanbul, Turkey
Duration: 13 Sep 200616 Sep 2006
Conference number: 5

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Evoked Potentials
Pain
Pain Perception
Somatosensory Evoked Potentials
Chronic Pain
Fingers
Electroencephalography
Volunteers
Healthy Volunteers
Brain

Keywords

  • METIS-235010

Cite this

Jongsma, M.A. ; van Rijn, C.M. ; van den Broeke, E. ; Postma, S. ; van der Lubbe, R. ; Buitenweg, J.R. ; Arns, M. ; Quian Quiroga, R. ; van Goor, H. ; Luckers, M. ; Wilder-Smith, O.H.G. / Effects of expectation on Somatosensory Event-related Potentials (SEPs) elicited by painful electric stimuli. In: Pain. 2006 ; Vol. 10, No. 1. pp. S71-S71.
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title = "Effects of expectation on Somatosensory Event-related Potentials (SEPs) elicited by painful electric stimuli",
abstract = "Background and Aims: Pain perception is typically measured by questionnaires and behavioural responses. Somatosensory Evoked Potentials (SEPs) however provide a direct measure of stimulus processing in the brain. To investigate whether expectancy influences SEPs we applied a cross‐modal oddball paradigm. The P3 EP component is modulated by expectancy, anticipation and novelty. We hypothesize that the number of background stimuli preceding the painful target determines the expectancy of the target and consequently the amplitude of the P3.Methods: A multi‐channel EEG was recorded (band pass 0.1–100 Hz, sample frequency 1000Hz) from 11 volunteers. Trials commenced with 3, to 11 auditory stimuli, followed by a painful electric target stimulus (ring finger, 1ms duration, individually set to a subjective pain intensity level of 9; 0 = no pain; 10 = maximum pain). Inter‐stimulus intervals were 800 ms. After target presentation the participants rated the stimulus painfulness (0–9).Results and Discussion: An increase in the number of auditory background stimuli preceding the painful stimulus was accompanied with a larger lateralised N130, possibly due to an increase in attention. The centrally localized P350 decreased, as hypothesized, as did the late N450. SEP changes were observed up to 7 preceding background stimuli, after which the effect levelled off. No effects of number of backgrounds was found with respect to the perceived intensity. We propose that SEP P350 components elicited by oddball paradigm behave similarly to P3 EP components observed in other modalities. It will be interesting to study whether cognitive SEP modulation differs between chronic pain patients and healthy volunteers.",
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author = "M.A. Jongsma and {van Rijn}, C.M. and {van den Broeke}, E. and S. Postma and {van der Lubbe}, R. and J.R. Buitenweg and M. Arns and {Quian Quiroga}, R. and {van Goor}, H. and M. Luckers and O.H.G. Wilder-Smith",
year = "2006",
doi = "10.1016/S1090-3801(06)60266-8",
language = "English",
volume = "10",
pages = "S71--S71",
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Jongsma, MA, van Rijn, CM, van den Broeke, E, Postma, S, van der Lubbe, R, Buitenweg, JR, Arns, M, Quian Quiroga, R, van Goor, H, Luckers, M & Wilder-Smith, OHG 2006, 'Effects of expectation on Somatosensory Event-related Potentials (SEPs) elicited by painful electric stimuli' Pain, vol. 10, no. 1, 263, pp. S71-S71. https://doi.org/10.1016/S1090-3801(06)60266-8

Effects of expectation on Somatosensory Event-related Potentials (SEPs) elicited by painful electric stimuli. / Jongsma, M.A.; van Rijn, C.M.; van den Broeke, E.; Postma, S.; van der Lubbe, R.; Buitenweg, J.R.; Arns, M.; Quian Quiroga, R.; van Goor, H.; Luckers, M.; Wilder-Smith, O.H.G.

In: Pain, Vol. 10, No. 1, 263, 2006, p. S71-S71.

Research output: Contribution to journalMeeting AbstractAcademic

TY - JOUR

T1 - Effects of expectation on Somatosensory Event-related Potentials (SEPs) elicited by painful electric stimuli

AU - Jongsma, M.A.

AU - van Rijn, C.M.

AU - van den Broeke, E.

AU - Postma, S.

AU - van der Lubbe, R.

AU - Buitenweg, J.R.

AU - Arns, M.

AU - Quian Quiroga, R.

AU - van Goor, H.

AU - Luckers, M.

AU - Wilder-Smith, O.H.G.

PY - 2006

Y1 - 2006

N2 - Background and Aims: Pain perception is typically measured by questionnaires and behavioural responses. Somatosensory Evoked Potentials (SEPs) however provide a direct measure of stimulus processing in the brain. To investigate whether expectancy influences SEPs we applied a cross‐modal oddball paradigm. The P3 EP component is modulated by expectancy, anticipation and novelty. We hypothesize that the number of background stimuli preceding the painful target determines the expectancy of the target and consequently the amplitude of the P3.Methods: A multi‐channel EEG was recorded (band pass 0.1–100 Hz, sample frequency 1000Hz) from 11 volunteers. Trials commenced with 3, to 11 auditory stimuli, followed by a painful electric target stimulus (ring finger, 1ms duration, individually set to a subjective pain intensity level of 9; 0 = no pain; 10 = maximum pain). Inter‐stimulus intervals were 800 ms. After target presentation the participants rated the stimulus painfulness (0–9).Results and Discussion: An increase in the number of auditory background stimuli preceding the painful stimulus was accompanied with a larger lateralised N130, possibly due to an increase in attention. The centrally localized P350 decreased, as hypothesized, as did the late N450. SEP changes were observed up to 7 preceding background stimuli, after which the effect levelled off. No effects of number of backgrounds was found with respect to the perceived intensity. We propose that SEP P350 components elicited by oddball paradigm behave similarly to P3 EP components observed in other modalities. It will be interesting to study whether cognitive SEP modulation differs between chronic pain patients and healthy volunteers.

AB - Background and Aims: Pain perception is typically measured by questionnaires and behavioural responses. Somatosensory Evoked Potentials (SEPs) however provide a direct measure of stimulus processing in the brain. To investigate whether expectancy influences SEPs we applied a cross‐modal oddball paradigm. The P3 EP component is modulated by expectancy, anticipation and novelty. We hypothesize that the number of background stimuli preceding the painful target determines the expectancy of the target and consequently the amplitude of the P3.Methods: A multi‐channel EEG was recorded (band pass 0.1–100 Hz, sample frequency 1000Hz) from 11 volunteers. Trials commenced with 3, to 11 auditory stimuli, followed by a painful electric target stimulus (ring finger, 1ms duration, individually set to a subjective pain intensity level of 9; 0 = no pain; 10 = maximum pain). Inter‐stimulus intervals were 800 ms. After target presentation the participants rated the stimulus painfulness (0–9).Results and Discussion: An increase in the number of auditory background stimuli preceding the painful stimulus was accompanied with a larger lateralised N130, possibly due to an increase in attention. The centrally localized P350 decreased, as hypothesized, as did the late N450. SEP changes were observed up to 7 preceding background stimuli, after which the effect levelled off. No effects of number of backgrounds was found with respect to the perceived intensity. We propose that SEP P350 components elicited by oddball paradigm behave similarly to P3 EP components observed in other modalities. It will be interesting to study whether cognitive SEP modulation differs between chronic pain patients and healthy volunteers.

KW - METIS-235010

U2 - 10.1016/S1090-3801(06)60266-8

DO - 10.1016/S1090-3801(06)60266-8

M3 - Meeting Abstract

VL - 10

SP - S71-S71

JO - Pain

JF - Pain

SN - 0304-3959

IS - 1

M1 - 263

ER -