Effects of Intra-Aortic Balloon Pump Timing on Baroreflex Activities in a Closed-Loop Cardiovascular Hybrid Model

Libera Fresiello, Ashraf William Khir*, Arianna Di Molfetta, Maciej Kozarski, Gianfranco Ferrari

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

Despite 50 years of research to assess the intra-aortic balloon pump (IABP) effects on patients' hemodynamics, some issues related to the effects of this therapy are still not fully understood. One of these issues is the effect of IABP, its inflation timing and duration on peripheral circulation autonomic controls. This work provides a systematic analysis of IABP effects on baroreflex using a cardiovascular hybrid model, which consists of computational and hydraulic submodels. The work also included a baroreflex computational model that was connected to a hydraulic model with a 40-cm3 balloon. The IABP was operated at different inflation trigger timings (-0.14 to 0.31s) and inflation durations (0.05-0.45s), with time of the dicrotic notch being taken as t=0. Baroreflex-dependent parameters-afferent and efferent pathway activity, heart rate, peripheral resistance, and venous tone-were evaluated at each of the inflation trigger times and durations considered. Balloon early inflation (0.09s before the dicrotic notch) with inflation duration of 0.25s generated a maximum net increment of afferent pathway activity of 10%, thus leading to a decrement of efferent sympathetic activity by 15.3% compared with baseline values. These times also resulted in a reduction in peripheral resistance and heart rate by 4 and 4.3% compared with baseline value. We conclude that optimum IABP triggering time results in positive effects on peripheral circulation autonomic controls. Conversely, if the balloon is not properly timed, peripheral resistance and heart rate may even increase, which could lead to detrimental outcomes.

Original languageEnglish
Pages (from-to)237-247
Number of pages11
JournalArtificial organs
Volume37
Issue number3
DOIs
Publication statusPublished - Mar 2013
Externally publishedYes

Keywords

  • Balloon timing
  • Baroreceptors
  • Hybrid model
  • Intra-aortic balloon pump

Fingerprint

Dive into the research topics of 'Effects of Intra-Aortic Balloon Pump Timing on Baroreflex Activities in a Closed-Loop Cardiovascular Hybrid Model'. Together they form a unique fingerprint.

Cite this