Efficiency of flow-driven adiabatic spin inversion under realistic experimental conditions: A computer simulation

Robert Trampel*, Thies H. Jochimsen, Toralf Mildner, David G. Norris, Harald E. Möller

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Abstract

Continuous arterial spin labeling (CASL) using adiabatic inversion is a widely used approach for perfusion imaging. For the quantification of perfusion, a reliable determination of the labeling efficiency is required. A numerical method for predicting the labeling efficiency in CASL experiments under various experimental conditions, including spin relaxation, is demonstrated. The approach is especially useful in the case of labeling at the carotid artery with a surface coil, as consideration of the experimental or theoretical profile of the B1 field is straightforward. Other effects that are also accounted for include deviations from a constant labeling gradient, and variations in the blood flow velocity due to the cardiac cycle. Assuming relevant experimental and physiological conditions, maximum inversion efficiencies of about 85% can be obtained.

Original languageEnglish
Pages (from-to)1187-1193
Number of pages7
JournalMagnetic resonance in medicine
Volume51
Issue number6
DOIs
Publication statusPublished - Jun 2004
Externally publishedYes

Keywords

  • Adiabatic inversion
  • Arterial spin labeling
  • Bloch equations
  • Perfusion
  • Surface coil
  • n/a OA procedure

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