Electrical and microfluidic technologies for organs-on-chips: Mimicking blood-brain barrier and gut tissues

Marieke Willemijn van der Helm

    Research output: ThesisPhD Thesis - Research UT, graduation UT

    373 Downloads (Pure)

    Abstract

    The goal of the research presented in this thesis is to develop new technologies for organs-on-chips to enable direct measurements of cell layer functions and to move towards high-throughput. In this introduction, a brief description is included of the tissues that were mimicked in the organs-on-chips described in this thesis. Next, conventional in vitro setups for mimicking these tissues are
    discussed as well as the advantages of organs-on-chips over these conventional in vitro models. Then, the most important tests of tissue function are described. Subsequently, the larger framework for the research described in this thesis is sketched and lastly an outline of the thesis is given.
    Original languageEnglish
    Awarding Institution
    • University of Twente
    Supervisors/Advisors
    • van den Berg, Albert , Supervisor
    • Eijkel, Jan C.T., Supervisor
    • Segerink, Loes Irene, Supervisor
    Award date19 Jan 2018
    Place of PublicationEnschede
    Publisher
    Print ISBNs978-90-365-4467-2
    DOIs
    Publication statusPublished - 19 Jan 2018

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    blood-brain barrier
    digestive system
    tissues
    testing
    cells

    Cite this

    van der Helm, Marieke Willemijn. / Electrical and microfluidic technologies for organs-on-chips : Mimicking blood-brain barrier and gut tissues. Enschede : University of Twente, 2018. 210 p.
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    abstract = "The goal of the research presented in this thesis is to develop new technologies for organs-on-chips to enable direct measurements of cell layer functions and to move towards high-throughput. In this introduction, a brief description is included of the tissues that were mimicked in the organs-on-chips described in this thesis. Next, conventional in vitro setups for mimicking these tissues arediscussed as well as the advantages of organs-on-chips over these conventional in vitro models. Then, the most important tests of tissue function are described. Subsequently, the larger framework for the research described in this thesis is sketched and lastly an outline of the thesis is given.",
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    Electrical and microfluidic technologies for organs-on-chips : Mimicking blood-brain barrier and gut tissues. / van der Helm, Marieke Willemijn.

    Enschede : University of Twente, 2018. 210 p.

    Research output: ThesisPhD Thesis - Research UT, graduation UT

    TY - THES

    T1 - Electrical and microfluidic technologies for organs-on-chips

    T2 - Mimicking blood-brain barrier and gut tissues

    AU - van der Helm, Marieke Willemijn

    PY - 2018/1/19

    Y1 - 2018/1/19

    N2 - The goal of the research presented in this thesis is to develop new technologies for organs-on-chips to enable direct measurements of cell layer functions and to move towards high-throughput. In this introduction, a brief description is included of the tissues that were mimicked in the organs-on-chips described in this thesis. Next, conventional in vitro setups for mimicking these tissues arediscussed as well as the advantages of organs-on-chips over these conventional in vitro models. Then, the most important tests of tissue function are described. Subsequently, the larger framework for the research described in this thesis is sketched and lastly an outline of the thesis is given.

    AB - The goal of the research presented in this thesis is to develop new technologies for organs-on-chips to enable direct measurements of cell layer functions and to move towards high-throughput. In this introduction, a brief description is included of the tissues that were mimicked in the organs-on-chips described in this thesis. Next, conventional in vitro setups for mimicking these tissues arediscussed as well as the advantages of organs-on-chips over these conventional in vitro models. Then, the most important tests of tissue function are described. Subsequently, the larger framework for the research described in this thesis is sketched and lastly an outline of the thesis is given.

    U2 - 10.3990/1.9789036544672

    DO - 10.3990/1.9789036544672

    M3 - PhD Thesis - Research UT, graduation UT

    SN - 978-90-365-4467-2

    PB - University of Twente

    CY - Enschede

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