Electrical and microfluidic technologies for organs-on-chips: Mimicking blood-brain barrier and gut tissues

Marieke Willemijn van der Helm

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

Abstract

The goal of the research presented in this thesis is to develop new technologies for organs-on-chips to enable direct measurements of cell layer functions and to move towards high-throughput. In this introduction, a brief description is included of the tissues that were mimicked in the organs-on-chips described in this thesis. Next, conventional in vitro setups for mimicking these tissues are
discussed as well as the advantages of organs-on-chips over these conventional in vitro models. Then, the most important tests of tissue function are described. Subsequently, the larger framework for the research described in this thesis is sketched and lastly an outline of the thesis is given.
LanguageEnglish
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • van den Berg, Albert , Supervisor
  • Eijkel, Jan C.T., Supervisor
  • Segerink, Loes Irene, Supervisor
Award date19 Jan 2018
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-4467-2
DOIs
Publication statusPublished - 19 Jan 2018

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blood-brain barrier
digestive system
tissues
testing
cells

Cite this

van der Helm, Marieke Willemijn. / Electrical and microfluidic technologies for organs-on-chips : Mimicking blood-brain barrier and gut tissues. Enschede : University of Twente, 2018. 210 p.
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Electrical and microfluidic technologies for organs-on-chips : Mimicking blood-brain barrier and gut tissues. / van der Helm, Marieke Willemijn.

Enschede : University of Twente, 2018. 210 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

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N2 - The goal of the research presented in this thesis is to develop new technologies for organs-on-chips to enable direct measurements of cell layer functions and to move towards high-throughput. In this introduction, a brief description is included of the tissues that were mimicked in the organs-on-chips described in this thesis. Next, conventional in vitro setups for mimicking these tissues arediscussed as well as the advantages of organs-on-chips over these conventional in vitro models. Then, the most important tests of tissue function are described. Subsequently, the larger framework for the research described in this thesis is sketched and lastly an outline of the thesis is given.

AB - The goal of the research presented in this thesis is to develop new technologies for organs-on-chips to enable direct measurements of cell layer functions and to move towards high-throughput. In this introduction, a brief description is included of the tissues that were mimicked in the organs-on-chips described in this thesis. Next, conventional in vitro setups for mimicking these tissues arediscussed as well as the advantages of organs-on-chips over these conventional in vitro models. Then, the most important tests of tissue function are described. Subsequently, the larger framework for the research described in this thesis is sketched and lastly an outline of the thesis is given.

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M3 - PhD Thesis - Research UT, graduation UT

SN - 978-90-365-4467-2

PB - University of Twente

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