Electrical Cross-Correlation Spectroscopy: Measuring Picoliter-per-Minute Flows in Nanochannels

Klaus Mathwig, Dileep Mampallil, Shuo Kang, Serge G. Lemay

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)
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Abstract

We introduce all-electrical cross-correlation spectroscopy of molecular number fluctuations in nanofluidic channels. Our approach is based on a pair of nanogap electrochemical transducers located downstream from each other in the channel. When liquid is driven through this device, mesoscopic fluctuations in the local density of molecules are transported along the channel. We perform a time-of-flight measurement of these fluctuations by cross-correlating current-time traces obtained at the two detectors. Thereby we are able to detect ultralow liquid flow rates below 10  pL/min⁡. This method constitutes the electrical equivalent of fluorescence cross-correlation spectroscopy.
Original languageEnglish
Article number118302
Number of pages5
JournalPhysical review letters
Volume109
Issue number11
DOIs
Publication statusPublished - 2012

Keywords

  • IR-84823
  • METIS-291162

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