Electrochemical nanofluidics: the mesoscopic limit

M.A.G. Zevenbergen, N. Wongrajit, P.S. Singh, E.D. Goluch, B.L. Wolfrum, S.G. Lemay

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    Abstract

    We have developed a lithography-based nanofluidic device for sensitive electrochemical detection applications. The device consists of a solution-filled channel bounded by parallel electrodes that are separated by ~50 nm. Redox cycling at the two electrodes is used to amplify the electrochemical signals from molecules in the volume between the electrodes, and can lead to dramatic improvements in sensitivity and/or selectivity. Interestingly, an important limit to sensitivity is placed by statistical fluctuations in the number of molecules present in the device, a consequence of its extremely small volume (a few femtolitres). In this Proceedings article, we focus on the consequences of these statistical fluctuations on the signal-to-noise ratio of electrochemical sensors based on redox cycling.
    Original languageEnglish
    Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
    EditorsSabeth Verpoorte, Helen Andersson-Svahn, Jenny Emnéus, Nicole Pamme
    Place of PublicationSan Diego
    PublisherThe Chemical and Biological Microsystems Society
    Pages1406-1408
    Number of pages3
    ISBN (Electronic)978-0-9798064-3-8
    ISBN (Print)978-1-6183906-2-2
    Publication statusPublished - 3 Oct 2010
    Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010 - Groningen, Netherlands
    Duration: 3 Oct 20107 Oct 2010
    Conference number: 14

    Publication series

    NameInternational Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]
    PublisherThe Chemical and Biological Microsystems Society
    Volume2010
    ISSN (Print)1556-5904

    Conference

    Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010
    Abbreviated titleMicroTAS
    CountryNetherlands
    CityGroningen
    Period3/10/107/10/10

    Keywords

    • Nanofluids
    • Electrochemistry
    • Sensing
    • Number fluctuations
    • Mesoscopic

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  • Cite this

    Zevenbergen, M. A. G., Wongrajit, N., Singh, P. S., Goluch, E. D., Wolfrum, B. L., & Lemay, S. G. (2010). Electrochemical nanofluidics: the mesoscopic limit. In S. Verpoorte, H. Andersson-Svahn, J. Emnéus, & N. Pamme (Eds.), 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 1406-1408). (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010). San Diego: The Chemical and Biological Microsystems Society.