Electrochemical nanofluidics: the mesoscopic limit

M.A.G. Zevenbergen; N. Wongrajit; P.S. Singh; E.D. Goluch; B.L. Wolfrum; S.G. Lemay

Electrochemical nanofluidics: the mesoscopic limit

M.A.G. Zevenbergen, N. Wongrajit, P.S. Singh, E.D. Goluch, B.L. Wolfrum, S.G. Lemay

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

We have developed a lithography-based nanofluidic device for sensitive electrochemical detection applications. The device consists of a solution-filled channel bounded by parallel electrodes that are separated by ~50 nm. Redox cycling at the two electrodes is used to amplify the electrochemical signals from molecules in the volume between the electrodes, and can lead to dramatic improvements in sensitivity and/or selectivity. Interestingly, an important limit to sensitivity is placed by statistical fluctuations in the number of molecules present in the device, a consequence of its extremely small volume (a few femtolitres). In this Proceedings article, we focus on the consequences of these statistical fluctuations on the signal-to-noise ratio of electrochemical sensors based on redox cycling.

Original language	English
Title of host publication	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Editors	Sabeth Verpoorte, Helen Andersson-Svahn, Jenny Emnéus, Nicole Pamme
Place of Publication	San Diego
Publisher	The Chemical and Biological Microsystems Society
Pages	1406-1408
Number of pages	3
ISBN (Electronic)	978-0-9798064-3-8
ISBN (Print)	978-1-6183906-2-2
Publication status	Published - 3 Oct 2010
Event	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010 - Groningen, Netherlands Duration: 3 Oct 2010 → 7 Oct 2010 Conference number: 14

Publication series

Name	International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]
Publisher	The Chemical and Biological Microsystems Society
Volume	2010
ISSN (Print)	1556-5904

Conference

Conference	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010
Abbreviated title	MicroTAS 2010
Country/Territory	Netherlands
City	Groningen
Period	3/10/10 → 7/10/10

Keywords

Nanofluids
Electrochemistry
Sensing
Number fluctuations
Mesoscopic

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Zevenbergen, M. A. G., Wongrajit, N., Singh, P. S., Goluch, E. D., Wolfrum, B. L., & Lemay, S. G. (2010). Electrochemical nanofluidics: the mesoscopic limit. In S. Verpoorte, H. Andersson-Svahn, J. Emnéus, & N. Pamme (Eds.), 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 1406-1408). (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010). The Chemical and Biological Microsystems Society.

Zevenbergen, M.A.G. ; Wongrajit, N. ; Singh, P.S. et al. / Electrochemical nanofluidics : the mesoscopic limit. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. editor / Sabeth Verpoorte ; Helen Andersson-Svahn ; Jenny Emnéus ; Nicole Pamme. San Diego : The Chemical and Biological Microsystems Society, 2010. pp. 1406-1408 (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]).

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title = "Electrochemical nanofluidics: the mesoscopic limit",

abstract = "We have developed a lithography-based nanofluidic device for sensitive electrochemical detection applications. The device consists of a solution-filled channel bounded by parallel electrodes that are separated by ~50 nm. Redox cycling at the two electrodes is used to amplify the electrochemical signals from molecules in the volume between the electrodes, and can lead to dramatic improvements in sensitivity and/or selectivity. Interestingly, an important limit to sensitivity is placed by statistical fluctuations in the number of molecules present in the device, a consequence of its extremely small volume (a few femtolitres). In this Proceedings article, we focus on the consequences of these statistical fluctuations on the signal-to-noise ratio of electrochemical sensors based on redox cycling.",

keywords = "Nanofluids, Electrochemistry, Sensing, Number fluctuations, Mesoscopic",

author = "M.A.G. Zevenbergen and N. Wongrajit and P.S. Singh and E.D. Goluch and B.L. Wolfrum and S.G. Lemay",

year = "2010",

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editor = "Sabeth Verpoorte and Helen Andersson-Svahn and Jenny Emn{\'e}us and Nicole Pamme",

booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",

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Zevenbergen, MAG, Wongrajit, N, Singh, PS, Goluch, ED, Wolfrum, BL & Lemay, SG 2010, Electrochemical nanofluidics: the mesoscopic limit. in S Verpoorte, H Andersson-Svahn, J Emnéus & N Pamme (eds), 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings], vol. 2010, The Chemical and Biological Microsystems Society, San Diego, pp. 1406-1408, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010, Groningen, Netherlands, 3/10/10.

Electrochemical nanofluidics: the mesoscopic limit. / Zevenbergen, M.A.G.; Wongrajit, N.; Singh, P.S. et al.
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. ed. / Sabeth Verpoorte; Helen Andersson-Svahn; Jenny Emnéus; Nicole Pamme. San Diego: The Chemical and Biological Microsystems Society, 2010. p. 1406-1408 (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Electrochemical nanofluidics

T2 - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010

AU - Zevenbergen, M.A.G.

AU - Wongrajit, N.

AU - Singh, P.S.

AU - Goluch, E.D.

AU - Wolfrum, B.L.

AU - Lemay, S.G.

N1 - Conference code: 14

PY - 2010/10/3

Y1 - 2010/10/3

N2 - We have developed a lithography-based nanofluidic device for sensitive electrochemical detection applications. The device consists of a solution-filled channel bounded by parallel electrodes that are separated by ~50 nm. Redox cycling at the two electrodes is used to amplify the electrochemical signals from molecules in the volume between the electrodes, and can lead to dramatic improvements in sensitivity and/or selectivity. Interestingly, an important limit to sensitivity is placed by statistical fluctuations in the number of molecules present in the device, a consequence of its extremely small volume (a few femtolitres). In this Proceedings article, we focus on the consequences of these statistical fluctuations on the signal-to-noise ratio of electrochemical sensors based on redox cycling.

AB - We have developed a lithography-based nanofluidic device for sensitive electrochemical detection applications. The device consists of a solution-filled channel bounded by parallel electrodes that are separated by ~50 nm. Redox cycling at the two electrodes is used to amplify the electrochemical signals from molecules in the volume between the electrodes, and can lead to dramatic improvements in sensitivity and/or selectivity. Interestingly, an important limit to sensitivity is placed by statistical fluctuations in the number of molecules present in the device, a consequence of its extremely small volume (a few femtolitres). In this Proceedings article, we focus on the consequences of these statistical fluctuations on the signal-to-noise ratio of electrochemical sensors based on redox cycling.

KW - Nanofluids

KW - Electrochemistry

KW - Sensing

KW - Number fluctuations

KW - Mesoscopic

M3 - Conference contribution

SN - 978-1-6183906-2-2

T3 - International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]

SP - 1406

EP - 1408

BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

A2 - Verpoorte, Sabeth

A2 - Andersson-Svahn, Helen

A2 - Emnéus, Jenny

A2 - Pamme, Nicole

PB - The Chemical and Biological Microsystems Society

CY - San Diego

Y2 - 3 October 2010 through 7 October 2010

ER -

Zevenbergen MAG, Wongrajit N, Singh PS, Goluch ED, Wolfrum BL, Lemay SG. Electrochemical nanofluidics: the mesoscopic limit. In Verpoorte S, Andersson-Svahn H, Emnéus J, Pamme N, editors, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. San Diego: The Chemical and Biological Microsystems Society. 2010. p. 1406-1408. (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]).

Electrochemical nanofluidics: the mesoscopic limit

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Keywords

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