Electrochemical protein cleavage in a microfluidic cell with integrated boron doped diamond electrodes

Floris Teunis Gerardus van den Brink, Tao Zhang, Liwei Ma, Mathieu Odijk, Wouter Olthuis, Hjalmar P. Permentier, Rainer P.H. Bischoff, Albert van den Berg

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    We present a microfluidic electrochemical cell with integrated boron doped diamond (BDD) electrodes which is designed for high electrochemical conversion efficiencies. With our newest developments, we aim to exploit the benefits of BDD as a novel electrode material to conduct tyrosine- and tryptophan- specific electrochemical protein cleavage for proteomics studies. Compared to traditional electrode materials, specific advantages of BDD include an extended potential window in aqueous solutions and a reduced susceptibility to fouling [1], which are properties that are particularly interesting for applications involving proteins or peptides [2].
    Original languageUndefined
    Title of host publicationThe 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015)
    PublisherChemical and Biological Micro Systems Society
    Pages1692-1694
    Number of pages3
    ISBN (Print)978-0-9798064-8-3
    Publication statusPublished - 25 Oct 2015
    Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015 - Hwabaek International Convention Center (HICO), Gyeongju, Korea, Republic of
    Duration: 25 Oct 201529 Oct 2015
    Conference number: 19
    http://www.rsc.org/images/LOC/2015/PDFs/Copyrite.pdf

    Publication series

    NameProceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS
    PublisherChemical and Biological Microsystems Society
    ISSN (Print)1556-5904

    Conference

    Conference19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015
    Abbreviated titleMicroTas 2015
    CountryKorea, Republic of
    CityGyeongju
    Period25/10/1529/10/15
    Internet address

    Keywords

    • EWI-26556
    • IR-98705
    • METIS-315090

    Cite this

    van den Brink, F. T. G., Zhang, T., Ma, L., Odijk, M., Olthuis, W., Permentier, H. P., ... van den Berg, A. (2015). Electrochemical protein cleavage in a microfluidic cell with integrated boron doped diamond electrodes. In The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015) (pp. 1692-1694). (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS). Chemical and Biological Micro Systems Society.