Electrochemical protein cleavage in a microfluidic cell with integrated boron doped diamond electrodes

Floris Teunis Gerardus van den Brink, Tao Zhang, Liwei Ma, Mathieu Odijk, Wouter Olthuis, Hjalmar P. Permentier, Rainer P.H. Bischoff, Albert van den Berg

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

We present a microfluidic electrochemical cell with integrated boron doped diamond (BDD) electrodes which is designed for high electrochemical conversion efficiencies. With our newest developments, we aim to exploit the benefits of BDD as a novel electrode material to conduct tyrosine- and tryptophan- specific electrochemical protein cleavage for proteomics studies. Compared to traditional electrode materials, specific advantages of BDD include an extended potential window in aqueous solutions and a reduced susceptibility to fouling [1], which are properties that are particularly interesting for applications involving proteins or peptides [2].
Original languageUndefined
Title of host publicationThe 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015)
PublisherChemical and Biological Micro Systems Society
Pages1692-1694
Number of pages3
ISBN (Print)978-0-9798064-8-3
Publication statusPublished - 25 Oct 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015 - Hwabaek International Convention Center (HICO), Gyeongju, Korea, Republic of
Duration: 25 Oct 201529 Oct 2015
Conference number: 19
http://www.rsc.org/images/LOC/2015/PDFs/Copyrite.pdf

Publication series

NameProceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS
PublisherChemical and Biological Microsystems Society
ISSN (Print)1556-5904

Conference

Conference19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015
Abbreviated titleMicroTas 2015
CountryKorea, Republic of
CityGyeongju
Period25/10/1529/10/15
Internet address

Keywords

  • EWI-26556
  • IR-98705
  • METIS-315090

Cite this

van den Brink, F. T. G., Zhang, T., Ma, L., Odijk, M., Olthuis, W., Permentier, H. P., ... van den Berg, A. (2015). Electrochemical protein cleavage in a microfluidic cell with integrated boron doped diamond electrodes. In The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015) (pp. 1692-1694). (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS). Chemical and Biological Micro Systems Society.
van den Brink, Floris Teunis Gerardus ; Zhang, Tao ; Ma, Liwei ; Odijk, Mathieu ; Olthuis, Wouter ; Permentier, Hjalmar P. ; Bischoff, Rainer P.H. ; van den Berg, Albert. / Electrochemical protein cleavage in a microfluidic cell with integrated boron doped diamond electrodes. The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015). Chemical and Biological Micro Systems Society, 2015. pp. 1692-1694 (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS).
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title = "Electrochemical protein cleavage in a microfluidic cell with integrated boron doped diamond electrodes",
abstract = "We present a microfluidic electrochemical cell with integrated boron doped diamond (BDD) electrodes which is designed for high electrochemical conversion efficiencies. With our newest developments, we aim to exploit the benefits of BDD as a novel electrode material to conduct tyrosine- and tryptophan- specific electrochemical protein cleavage for proteomics studies. Compared to traditional electrode materials, specific advantages of BDD include an extended potential window in aqueous solutions and a reduced susceptibility to fouling [1], which are properties that are particularly interesting for applications involving proteins or peptides [2].",
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van den Brink, FTG, Zhang, T, Ma, L, Odijk, M, Olthuis, W, Permentier, HP, Bischoff, RPH & van den Berg, A 2015, Electrochemical protein cleavage in a microfluidic cell with integrated boron doped diamond electrodes. in The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015). Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS, Chemical and Biological Micro Systems Society, pp. 1692-1694, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015, Gyeongju, Korea, Republic of, 25/10/15.

Electrochemical protein cleavage in a microfluidic cell with integrated boron doped diamond electrodes. / van den Brink, Floris Teunis Gerardus; Zhang, Tao; Ma, Liwei; Odijk, Mathieu; Olthuis, Wouter; Permentier, Hjalmar P.; Bischoff, Rainer P.H.; van den Berg, Albert.

The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015). Chemical and Biological Micro Systems Society, 2015. p. 1692-1694 (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Electrochemical protein cleavage in a microfluidic cell with integrated boron doped diamond electrodes

AU - van den Brink, Floris Teunis Gerardus

AU - Zhang, Tao

AU - Ma, Liwei

AU - Odijk, Mathieu

AU - Olthuis, Wouter

AU - Permentier, Hjalmar P.

AU - Bischoff, Rainer P.H.

AU - van den Berg, Albert

N1 - eemcs-eprint-26556

PY - 2015/10/25

Y1 - 2015/10/25

N2 - We present a microfluidic electrochemical cell with integrated boron doped diamond (BDD) electrodes which is designed for high electrochemical conversion efficiencies. With our newest developments, we aim to exploit the benefits of BDD as a novel electrode material to conduct tyrosine- and tryptophan- specific electrochemical protein cleavage for proteomics studies. Compared to traditional electrode materials, specific advantages of BDD include an extended potential window in aqueous solutions and a reduced susceptibility to fouling [1], which are properties that are particularly interesting for applications involving proteins or peptides [2].

AB - We present a microfluidic electrochemical cell with integrated boron doped diamond (BDD) electrodes which is designed for high electrochemical conversion efficiencies. With our newest developments, we aim to exploit the benefits of BDD as a novel electrode material to conduct tyrosine- and tryptophan- specific electrochemical protein cleavage for proteomics studies. Compared to traditional electrode materials, specific advantages of BDD include an extended potential window in aqueous solutions and a reduced susceptibility to fouling [1], which are properties that are particularly interesting for applications involving proteins or peptides [2].

KW - EWI-26556

KW - IR-98705

KW - METIS-315090

M3 - Conference contribution

SN - 978-0-9798064-8-3

T3 - Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS

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EP - 1694

BT - The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015)

PB - Chemical and Biological Micro Systems Society

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van den Brink FTG, Zhang T, Ma L, Odijk M, Olthuis W, Permentier HP et al. Electrochemical protein cleavage in a microfluidic cell with integrated boron doped diamond electrodes. In The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015). Chemical and Biological Micro Systems Society. 2015. p. 1692-1694. (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS).