Electrochemical sensing in paper-based microfluidic devices

Zhihong Nie, Christian A. Nijhuis, Jinlong Gong, Xin Chen, Alexander Kumachev, Andres W. Martinez, Max Narovlyansky, George M. Whitesides*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

824 Citations (Scopus)


This paper describes the fabrication and the performance of microfluidic paper-based electrochemical sensing devices (we call the microfluidic paper-based electrochemical devices, µPEDs). The µPEDs comprise paper-based microfluidic channels patterned by photolithography or wax printing, and electrodes screen-printed from conducting inks (e.g., carbon or Ag/AgCl). We demonstrated that the µPEDs are capable of quantifying the concentrations of various analytes (e.g., heavy-metal ions and glucose) in aqueous solutions. This low-cost analytical device should be useful for applications in public health, environmental monitoring, and the developing world.

Original languageEnglish
Pages (from-to)477-483
JournalLab on a chip
Issue number4
Publication statusPublished - 2010
Externally publishedYes


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