Electrochemical Single-Molecule Detection in Aqueous Solution Using Self-Aligned Nanogap Transducers

Shuo Kang; Albert F. Nieuwenhuis; Klaus Mathwig; Dileep Mampallil Augustine; Serge Joseph Guy Lemay

doi:10.1021/nn404440v

Electrochemical Single-Molecule Detection in Aqueous Solution Using Self-Aligned Nanogap Transducers

Shuo Kang, Albert F. Nieuwenhuis, Klaus Mathwig, Dileep Mampallil Augustine, Serge Joseph Guy Lemay

Faculty of Science and Technology

Research output: Contribution to journal › Article › Academic › peer-review

53 Citations (Scopus)

Abstract

Electrochemical detection of individual molecular tags in nanochannels may enable cost-effective, massively parallel analysis and diagnostics platforms. Here we demonstrate single-molecule detection of prototypical analytes in aqueous solution based on redox cycling in 40 nm nanogap transducers. These nanofluidic devices are fabricated using standard microfabrication techniques combined with a self-aligned approach that minimizes gap size and dead volume. We demonstrate the detection of three common redox mediators at physiological salt concentrations.

Original language	English
Pages (from-to)	10931-10937
Journal	ACS nano
Volume	7
Issue number	12
DOIs	https://doi.org/10.1021/nn404440v
Publication status	Published - 26 Nov 2013

Keywords

METIS-309979
IR-95449

Access to Document

10.1021/nn404440v

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Kang, S., Nieuwenhuis, A. F., Mathwig, K., Mampallil Augustine, D., & Lemay, S. J. G. (2013). Electrochemical Single-Molecule Detection in Aqueous Solution Using Self-Aligned Nanogap Transducers. ACS nano, 7(12), 10931-10937. https://doi.org/10.1021/nn404440v

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