Abstract
Electrochemical detection of individual molecular tags in nanochannels may enable cost-effective, massively parallel analysis and diagnostics platforms. Here we demonstrate single-molecule detection of prototypical analytes in aqueous solution based on redox cycling in 40 nm nanogap transducers. These nanofluidic devices are fabricated using standard microfabrication techniques combined with a self-aligned approach that minimizes gap size and dead volume. We demonstrate the detection of three common redox mediators at physiological salt concentrations.
Original language | English |
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Pages (from-to) | 10931-10937 |
Journal | ACS nano |
Volume | 7 |
Issue number | 12 |
DOIs | |
Publication status | Published - 26 Nov 2013 |
Keywords
- METIS-309979
- IR-95449