TY - JOUR
T1 - Electrochemistry of potential bioreductive alkylating quinones
T2 - Part 2. Electrochemical properties of 2,5-bis(1-aziridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone and some model compounds
AU - Driebergen, R.J.
AU - Holthuis, J.J.M.
AU - Blauw, J.S.
AU - Postma Kelder, S.J.
AU - Verboom, W.
AU - Reinhoudt, D.N.
AU - van der Linden, W.E.
PY - 1990
Y1 - 1990
N2 - The reduction mechanism of 2,5-bis(1-aziridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone (Diaziquone, AZQ) and several model compounds of the mono- and bis(1-aziridinyl)quinone type at the dropping mercury electrode in aqueous solutions was studied. In addition, the influence of methyl substitution of the aziridinyl moiety at the 2-position on the protonation of the aziridine nitrogen was investigated. Substituent effects on quinone reduction and aziridine protonation prior to and following quinone reduction were studied qualitatively.
AB - The reduction mechanism of 2,5-bis(1-aziridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone (Diaziquone, AZQ) and several model compounds of the mono- and bis(1-aziridinyl)quinone type at the dropping mercury electrode in aqueous solutions was studied. In addition, the influence of methyl substitution of the aziridinyl moiety at the 2-position on the protonation of the aziridine nitrogen was investigated. Substituent effects on quinone reduction and aziridine protonation prior to and following quinone reduction were studied qualitatively.
KW - Controlled potential electrolysis
KW - Aziridinylquinones
KW - Bis(1-aziridinyl)bis(ethoxycarbonylamino)-benzoquinone
KW - Quinones
U2 - 10.1016/S0003-2670(00)83570-9
DO - 10.1016/S0003-2670(00)83570-9
M3 - Article
VL - 234
SP - 285
EP - 307
JO - Analytica chimica acta
JF - Analytica chimica acta
SN - 0003-2670
ER -