TY - JOUR
T1 - Electrochemistry of potentially bioreductive alkylating quinones
T2 - Part 1. Electrochemical properties of relatively simple quinones, as model compounds of mitomycin- and aziridinylquinone-type antitumour agents
AU - Driebergen, R.J.
AU - den Hartigh, J.
AU - Holthuis, J.J.M.
AU - Hulshoff, A.
AU - van Oort, W.J.
AU - Postma Kelder, S.J.
AU - Verboom, W.
AU - Reinhoudt, D.N.
AU - Bos, M.
AU - van der Linden, W.E.
PY - 1990
Y1 - 1990
N2 - The influence of methyl-, hydroxy and amino substituents on the electrochemical behaviour of simple 1,4-naphtho-and 1,4-benzoquinones, model compounds of many quinoid antitumour agents, in aqueous media was studied. Significant changes in electrochemical behaviour were observed, potentially the result of a change in the electron density of the quinone moiety, pre- or post-protonation of substituents, hydrogen bond formation, tautomerization reactions and steric interactions between the quinone moiety and substituents. The information obtained was of benefit in the elucidation of the reduction mechanisms of quinoid antitumour agents such as aziridnylquinones and mitomycins.
AB - The influence of methyl-, hydroxy and amino substituents on the electrochemical behaviour of simple 1,4-naphtho-and 1,4-benzoquinones, model compounds of many quinoid antitumour agents, in aqueous media was studied. Significant changes in electrochemical behaviour were observed, potentially the result of a change in the electron density of the quinone moiety, pre- or post-protonation of substituents, hydrogen bond formation, tautomerization reactions and steric interactions between the quinone moiety and substituents. The information obtained was of benefit in the elucidation of the reduction mechanisms of quinoid antitumour agents such as aziridnylquinones and mitomycins.
U2 - 10.1016/S0003-2670(00)83486-8
DO - 10.1016/S0003-2670(00)83486-8
M3 - Article
VL - 233
SP - 251
EP - 268
JO - Analytica chimica acta
JF - Analytica chimica acta
SN - 0003-2670
ER -