Electroosmotic guiding of sample flows in a laminar flow chamber

Geert A.J. Besselink, Paul Vulto, Rob G.H. Lammertink, Stefan Schlautmann, Albert van den Berg, Wouter Olthuis, Gerard H.M. Engbers, Richard B.M. Schasfoort

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24 Citations (Scopus)


The so-called address-flow principle is described: a valveless, electroosmotically driven technology used for controlling the stream profile in a laminar flow chamber. The method is explained, and a theoretical description and experimental verification are presented. Adjustment of the flow of two electroosmotically controlled guiding streams, running parallel to a central sample stream, can be used for positioning the sample stream in the dimension perpendicular to the flow direction. The results presented show that address-flow microfluidics allow easy and accurate control of sample stream position and width. The electroosmotic flow (EOF)-controlled guiding of microfluidic flows described in this paper, is a new unit operation that might aid in separation and collection in microfluidic devices. One possible application of addressflow microfluidics is guiding of capillary electrophoresis-separated components over a multisensor array, in order to perform affinity assays.
Original languageEnglish
Pages (from-to)3705-3711
Number of pages7
Issue number21-22
Publication statusPublished - 2004


  • Micro-fabrication
  • Miniaturization
  • Address flow
  • Micro-fluidics
  • Electro-osmotic flow

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