Electrospinning: A Fast Process for Imprinting Micro and Nano Patterns on Electrospun Fiber Meshes at Physiological Temperatures

Anandkumar Nandakumar, Roman Truckenmüller, Maqsood Ahmed, Febriyani Damanik, Diogo Reis Santos, Nils Auffermann, Jan de Boer, Pamela Habibovic, Clemens van Blitterswijk, Lorenzo Moroni*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)


Electrospun fiber meshes are patterned at length scales comparable to or lower than their fiber diameter. Simple nano- and microgrooves and closed geometric shapes are imprinted in different tones using a fast imprint process at physiological temperatures. Human mesenchymal stromal cells cultured on patterned scaffolds show differences in cellular morphology and cytoskeleton organization. Microgrooved electrospun fibers support upregulation of alkaline phosphatase and bone morphogenetic protein-2 gene expression when cells are cultured in osteogenic medium.
Original languageEnglish
Pages (from-to)3405-3409
Issue number20
Publication statusPublished - 27 Feb 2013


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