Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches

Anne Marijke Leferink, D. Schipper, E. Arts, E.J. Vrij, N.C. Rivron, Hermanus Bernardus Johannes Karperien, K. Mittmann, Clemens van Blitterswijk, Lorenzo Moroni, R.K. Truckenmüller

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Abstract

A material-based bottom-up approach is proposed towards an assembly of cells and engineered micro-objects at the macroscale. We show how shape, size and wettability of engineered micro-objects play an important role in the behavior of cells on these objects. This approach can, among other applications, be used as a tool to engineer complex 3D tissues of clinically relevant size.
Original languageEnglish
Pages (from-to)2592-2599
JournalAdvanced materials
Volume26
Issue number16
DOIs
Publication statusPublished - 7 Jan 2014

Keywords

  • METIS-299945
  • IR-88436

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