Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches

A. Leferink; D. Schipper; E. Arts; E. Vrij; N. Rivron; M. Karperien; K. Mittmann; C. van Blitterswijk; L. Moroni; R. Truckenmüller

doi:10.1002/adma.201304539

Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches

A. Leferink, D. Schipper, E. Arts, E. Vrij, N. Rivron, M. Karperien, K. Mittmann, C. van Blitterswijk, L. Moroni^*, R. Truckenmüller^*

^*Corresponding author for this work

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Abstract

A material-based bottom-up approach is proposed towards an assembly of cells and engineered micro-objects at the macroscale. We show how shape, size and wettability of engineered micro-objects play an important role in the behavior of cells on these objects. This approach can, among other applications, be used as a tool to engineer complex 3D tissues of clinically relevant size.

Original language	English
Pages (from-to)	2592-2599
Journal	Advanced materials
Volume	26
Issue number	16
DOIs	https://doi.org/10.1002/adma.201304539
Publication status	Published - 7 Jan 2014

Keywords

2023 OA procedure

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ArticleFinal published version, 1.29 MBLicence: Taverne

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title = "Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches",

abstract = "A material-based bottom-up approach is proposed towards an assembly of cells and engineered micro-objects at the macroscale. We show how shape, size and wettability of engineered micro-objects play an important role in the behavior of cells on these objects. This approach can, among other applications, be used as a tool to engineer complex 3D tissues of clinically relevant size.",

keywords = "2023 OA procedure",

author = "A. Leferink and D. Schipper and E. Arts and E. Vrij and N. Rivron and M. Karperien and K. Mittmann and {van Blitterswijk}, C. and L. Moroni and R. Truckenm{\"u}ller",

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AU - Leferink, A.

AU - Schipper, D.

AU - Arts, E.

AU - Vrij, E.

AU - Rivron, N.

AU - Karperien, M.

AU - Mittmann, K.

AU - van Blitterswijk, C.

AU - Moroni, L.

AU - Truckenmüller, R.

PY - 2014/1/7

Y1 - 2014/1/7

N2 - A material-based bottom-up approach is proposed towards an assembly of cells and engineered micro-objects at the macroscale. We show how shape, size and wettability of engineered micro-objects play an important role in the behavior of cells on these objects. This approach can, among other applications, be used as a tool to engineer complex 3D tissues of clinically relevant size.

AB - A material-based bottom-up approach is proposed towards an assembly of cells and engineered micro-objects at the macroscale. We show how shape, size and wettability of engineered micro-objects play an important role in the behavior of cells on these objects. This approach can, among other applications, be used as a tool to engineer complex 3D tissues of clinically relevant size.

KW - 2023 OA procedure

U2 - 10.1002/adma.201304539

DO - 10.1002/adma.201304539

M3 - Article

SN - 0935-9648

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EP - 2599

JO - Advanced materials

JF - Advanced materials

IS - 16

ER -

Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches

Abstract

Keywords

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