Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response

A. Vishwakarma, N.S. Bhise, M.B. Evangelista, Jeroen Rouwkema, M.R. Dokmeci, A.M. Ghaemmaghami, N.E. Vrana, A. Khademhosseini

Research output: Contribution to journalArticleAcademicpeer-review

87 Citations (Scopus)

Abstract

Current state-of-the-art biomedical implants and tissue engineering methods promise technologies to improve or even restore the function of diseased organs. However, one of the biggest challenges to clinical success is the lack of functional integration. A series of cellular and molecular events following biomaterial implantation poses an important bottleneck for developing breakthrough solutions. With inflammation increasingly recognized as a crucial component influencing regeneration, immunomodulation or immuno-engineering has emerged as a potential solution to overcome this key challenge in regenerative medicine. We postulate possibilities to utilize biomaterial physicochemical modifications to modulate the host inflammatory response and develop strategies for effective biomaterial integration. Biomaterial-based immunomodulation strategies can significantly ameliorate the outcomes of medical implants and tissue engineering therapies.
Original languageEnglish
Pages (from-to)470-482
Number of pages13
JournalTrends in biotechnology
Volume34
Issue number6
DOIs
Publication statusPublished - 2016

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Biocompatible Materials
Biomaterials
Immunomodulation
Tissue Engineering
Tissue engineering
Biomedical Engineering
Regenerative Medicine
Cell- and Tissue-Based Therapy
Regeneration
Inflammation
Technology

Keywords

  • METIS-316992
  • IR-100694

Cite this

Vishwakarma, A., Bhise, N. S., Evangelista, M. B., Rouwkema, J., Dokmeci, M. R., Ghaemmaghami, A. M., ... Khademhosseini, A. (2016). Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response. Trends in biotechnology, 34(6), 470-482. https://doi.org/10.1016/j.tibtech.2016.03.009
Vishwakarma, A. ; Bhise, N.S. ; Evangelista, M.B. ; Rouwkema, Jeroen ; Dokmeci, M.R. ; Ghaemmaghami, A.M. ; Vrana, N.E. ; Khademhosseini, A. / Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response. In: Trends in biotechnology. 2016 ; Vol. 34, No. 6. pp. 470-482.
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Vishwakarma, A, Bhise, NS, Evangelista, MB, Rouwkema, J, Dokmeci, MR, Ghaemmaghami, AM, Vrana, NE & Khademhosseini, A 2016, 'Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response' Trends in biotechnology, vol. 34, no. 6, pp. 470-482. https://doi.org/10.1016/j.tibtech.2016.03.009

Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response. / Vishwakarma, A.; Bhise, N.S.; Evangelista, M.B.; Rouwkema, Jeroen; Dokmeci, M.R.; Ghaemmaghami, A.M.; Vrana, N.E.; Khademhosseini, A.

In: Trends in biotechnology, Vol. 34, No. 6, 2016, p. 470-482.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Vishwakarma, A.

AU - Bhise, N.S.

AU - Evangelista, M.B.

AU - Rouwkema, Jeroen

AU - Dokmeci, M.R.

AU - Ghaemmaghami, A.M.

AU - Vrana, N.E.

AU - Khademhosseini, A.

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KW - IR-100694

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JO - Trends in biotechnology

JF - Trends in biotechnology

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