Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 470-482 |
| Number of pages | 13 |
| Journal | Trends in biotechnology |
| Volume | 34 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- METIS-316992
- IR-100694
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Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response. / Vishwakarma, A.; Bhise, N.S.; Evangelista, M.B.; Rouwkema, Jeroen; Dokmeci, M.R.; Ghaemmaghami, A.M.; Vrana, N.E.; Khademhosseini, A.
In: Trends in biotechnology, Vol. 34, No. 6, 2016, p. 470-482.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response
AU - Vishwakarma, A.
AU - Bhise, N.S.
AU - Evangelista, M.B.
AU - Rouwkema, Jeroen
AU - Dokmeci, M.R.
AU - Ghaemmaghami, A.M.
AU - Vrana, N.E.
AU - Khademhosseini, A.
PY - 2016
Y1 - 2016
N2 - Current state-of-the-art biomedical implants and tissue engineering methods promise technologies to improve or even restore the function of diseased organs. However, one of the biggest challenges to clinical success is the lack of functional integration. A series of cellular and molecular events following biomaterial implantation poses an important bottleneck for developing breakthrough solutions. With inflammation increasingly recognized as a crucial component influencing regeneration, immunomodulation or immuno-engineering has emerged as a potential solution to overcome this key challenge in regenerative medicine. We postulate possibilities to utilize biomaterial physicochemical modifications to modulate the host inflammatory response and develop strategies for effective biomaterial integration. Biomaterial-based immunomodulation strategies can significantly ameliorate the outcomes of medical implants and tissue engineering therapies.
AB - Current state-of-the-art biomedical implants and tissue engineering methods promise technologies to improve or even restore the function of diseased organs. However, one of the biggest challenges to clinical success is the lack of functional integration. A series of cellular and molecular events following biomaterial implantation poses an important bottleneck for developing breakthrough solutions. With inflammation increasingly recognized as a crucial component influencing regeneration, immunomodulation or immuno-engineering has emerged as a potential solution to overcome this key challenge in regenerative medicine. We postulate possibilities to utilize biomaterial physicochemical modifications to modulate the host inflammatory response and develop strategies for effective biomaterial integration. Biomaterial-based immunomodulation strategies can significantly ameliorate the outcomes of medical implants and tissue engineering therapies.
KW - METIS-316992
KW - IR-100694
U2 - 10.1016/j.tibtech.2016.03.009
DO - 10.1016/j.tibtech.2016.03.009
M3 - Article
VL - 34
SP - 470
EP - 482
JO - Trends in biotechnology
JF - Trends in biotechnology
SN - 0167-7799
IS - 6
ER -