Engineering microbubbles for precision medicine with ultrasound

Michel Versluis*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Bubble acoustics has widespread use in medical technology and nanotechnology. The applications include in particular local drug delivery or local, well-controlled surface cleaning and promotion of efficient mixing on the microscale through acoustic streaming. Microbubbles and nanodroplets consisting of a low-boiling point liquid can be engineered and actuated by means of bulk and surface acoustic waves. These agents can also be decorated with a payload, which carries great potential for their use as drug delivery agents in the context of personalized medical therapy. Key to all these emerging applications is a precise acoustic control of the interaction of ultrasound with the bubbles and droplets. The challenge here is the combined microscopic length scales and ultrashort time scales associated with the mechanisms governing bubble formation and its activation processes, which we solve by high-resolution ultrafast microscopy, even down to the nanoseconds. Together with theoretical modeling and numerical simulations these experiments assist our in-depth fundamental understanding of bubble behavior and provides intriguing new prospects for innovative solutions in nanotechnology industry and in nanomedicine.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherThe Chemical and Biological Microsystems Society
Pages241-244
Number of pages4
ISBN (Electronic)9780692941836
Publication statusPublished - 1 Jan 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017 - Savannah International Trade & Convention Center, Savannah, United States
Duration: 22 Oct 201726 Oct 2017
Conference number: 21
https://www.microtas2017.org/

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017
Abbreviated titleMicroTAS
CountryUnited States
CitySavannah
Period22/10/1726/10/17
Internet address

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Keywords

  • Acoustofluidics
  • Molecular imaging
  • Targeted therapy
  • Ultrasound contrast agents

Cite this

Versluis, M. (2020). Engineering microbubbles for precision medicine with ultrasound. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 241-244). The Chemical and Biological Microsystems Society.