Engineering vascularised tissues in vitro

N.C. Rivron, N.C. Rivron, J. Liu, Jeroen Rouwkema, Jan de Boer, Clemens van Blitterswijk

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Tissue engineering aims at replacing or regenerating tissues lost due to diseases or traumas (Langer and Vacanti, 1993). However, mimicking in vitro the physiological complexity of vascularized tissue is a major obstacle, which possibly contributes to impaired healing in vivo. In higher organisms, native features including the vascular network, the lymphatic networks and interstitial flow promote both mass transport and organ development. Attempts to mimic those features in engineered tissues will lead to more clinically relevant cell-based therapies. Aside from current strategies promoting angiogenesis from the host, an alternative concept termed prevascularization is emerging. It aims at creating a biological vasculature inside an engineered tissue prior to implantation. This vasculature can rapidly anastamose with the host and enhances tissue survival and differentiation. Interestingly, growing evidence supports a role of the vasculature in regulating pattern formation and tissue differentiation. Thus, prevascularized tissues also benefit from an intrinsic contribution of their vascular system to their development. From those early attempts are emerging a body of principles and strategies to grow and maintain, in vitro, those self-assembled biological vascular networks. This could lead to the generation of engineered tissues of more physiologically relevant complexity and improved regenerative potential.
Original languageUndefined
Pages (from-to)27-40
JournalEuropean cells & materials
Volume15
Publication statusPublished - 2008

Keywords

  • IR-68573
  • METIS-253231

Cite this

Rivron, N. C., Rivron, N. C., Liu, J., Rouwkema, J., de Boer, J., & van Blitterswijk, C. (2008). Engineering vascularised tissues in vitro. European cells & materials, 15, 27-40.
Rivron, N.C. ; Rivron, N.C. ; Liu, J. ; Rouwkema, Jeroen ; de Boer, Jan ; van Blitterswijk, Clemens. / Engineering vascularised tissues in vitro. In: European cells & materials. 2008 ; Vol. 15. pp. 27-40.
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abstract = "Tissue engineering aims at replacing or regenerating tissues lost due to diseases or traumas (Langer and Vacanti, 1993). However, mimicking in vitro the physiological complexity of vascularized tissue is a major obstacle, which possibly contributes to impaired healing in vivo. In higher organisms, native features including the vascular network, the lymphatic networks and interstitial flow promote both mass transport and organ development. Attempts to mimic those features in engineered tissues will lead to more clinically relevant cell-based therapies. Aside from current strategies promoting angiogenesis from the host, an alternative concept termed prevascularization is emerging. It aims at creating a biological vasculature inside an engineered tissue prior to implantation. This vasculature can rapidly anastamose with the host and enhances tissue survival and differentiation. Interestingly, growing evidence supports a role of the vasculature in regulating pattern formation and tissue differentiation. Thus, prevascularized tissues also benefit from an intrinsic contribution of their vascular system to their development. From those early attempts are emerging a body of principles and strategies to grow and maintain, in vitro, those self-assembled biological vascular networks. This could lead to the generation of engineered tissues of more physiologically relevant complexity and improved regenerative potential.",
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year = "2008",
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journal = "European cells & materials",
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Rivron, NC, Rivron, NC, Liu, J, Rouwkema, J, de Boer, J & van Blitterswijk, C 2008, 'Engineering vascularised tissues in vitro' European cells & materials, vol. 15, pp. 27-40.

Engineering vascularised tissues in vitro. / Rivron, N.C.; Rivron, N.C.; Liu, J.; Rouwkema, Jeroen; de Boer, Jan; van Blitterswijk, Clemens.

In: European cells & materials, Vol. 15, 2008, p. 27-40.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Engineering vascularised tissues in vitro

AU - Rivron, N.C.

AU - Rivron, N.C.

AU - Liu, J.

AU - Rouwkema, Jeroen

AU - de Boer, Jan

AU - van Blitterswijk, Clemens

PY - 2008

Y1 - 2008

N2 - Tissue engineering aims at replacing or regenerating tissues lost due to diseases or traumas (Langer and Vacanti, 1993). However, mimicking in vitro the physiological complexity of vascularized tissue is a major obstacle, which possibly contributes to impaired healing in vivo. In higher organisms, native features including the vascular network, the lymphatic networks and interstitial flow promote both mass transport and organ development. Attempts to mimic those features in engineered tissues will lead to more clinically relevant cell-based therapies. Aside from current strategies promoting angiogenesis from the host, an alternative concept termed prevascularization is emerging. It aims at creating a biological vasculature inside an engineered tissue prior to implantation. This vasculature can rapidly anastamose with the host and enhances tissue survival and differentiation. Interestingly, growing evidence supports a role of the vasculature in regulating pattern formation and tissue differentiation. Thus, prevascularized tissues also benefit from an intrinsic contribution of their vascular system to their development. From those early attempts are emerging a body of principles and strategies to grow and maintain, in vitro, those self-assembled biological vascular networks. This could lead to the generation of engineered tissues of more physiologically relevant complexity and improved regenerative potential.

AB - Tissue engineering aims at replacing or regenerating tissues lost due to diseases or traumas (Langer and Vacanti, 1993). However, mimicking in vitro the physiological complexity of vascularized tissue is a major obstacle, which possibly contributes to impaired healing in vivo. In higher organisms, native features including the vascular network, the lymphatic networks and interstitial flow promote both mass transport and organ development. Attempts to mimic those features in engineered tissues will lead to more clinically relevant cell-based therapies. Aside from current strategies promoting angiogenesis from the host, an alternative concept termed prevascularization is emerging. It aims at creating a biological vasculature inside an engineered tissue prior to implantation. This vasculature can rapidly anastamose with the host and enhances tissue survival and differentiation. Interestingly, growing evidence supports a role of the vasculature in regulating pattern formation and tissue differentiation. Thus, prevascularized tissues also benefit from an intrinsic contribution of their vascular system to their development. From those early attempts are emerging a body of principles and strategies to grow and maintain, in vitro, those self-assembled biological vascular networks. This could lead to the generation of engineered tissues of more physiologically relevant complexity and improved regenerative potential.

KW - IR-68573

KW - METIS-253231

M3 - Article

VL - 15

SP - 27

EP - 40

JO - European cells & materials

JF - European cells & materials

SN - 1473-2262

ER -

Rivron NC, Rivron NC, Liu J, Rouwkema J, de Boer J, van Blitterswijk C. Engineering vascularised tissues in vitro. European cells & materials. 2008;15:27-40.