Enhanced surface plasmon resonance inhibition test (ESPRIT) using latex particles

A.H. Severs*, R.B.M. Schasfoort

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Scopus)
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The pregnancy hormone human chorionic gonadotropin (hCG) was used as a model antigen to describe a new assay, the Enhanced Surface Plasmon Resonance Inhibition Test (ESPRIT). It was shown that the introduction of sub-micron latex particles instead of anti-antibodies in an enhancement step improved the sensitivity of the assay by a factor of 30. Latex particles are therefore considered to be versatile tools in the development of new immunochemical assays for the detection of any analyte using SPR immunosensors.

Original languageEnglish
Pages (from-to)365-370
Number of pages6
JournalBiosensors & bioelectronics
Issue number7-8
Publication statusPublished - 1 Jan 1993
Externally publishedYes


  • Human chorionic gonadotropin
  • Sub-micron latex particles
  • Surface plasmon resonance


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