Enhanced surface plasmon resonance inhibition test (ESPRIT) using latex particles

A.H. Severs; R.B.M. Schasfoort

doi:10.1016/0956-5663(93)80075-Z

Enhanced surface plasmon resonance inhibition test (ESPRIT) using latex particles

A.H. Severs^*, R.B.M. Schasfoort

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The pregnancy hormone human chorionic gonadotropin (hCG) was used as a model antigen to describe a new assay, the Enhanced Surface Plasmon Resonance Inhibition Test (ESPRIT). It was shown that the introduction of sub-micron latex particles instead of anti-antibodies in an enhancement step improved the sensitivity of the assay by a factor of 30. Latex particles are therefore considered to be versatile tools in the development of new immunochemical assays for the detection of any analyte using SPR immunosensors.

Original language	English
Pages (from-to)	365-370
Number of pages	6
Journal	Biosensors & bioelectronics
Volume	8
Issue number	7-8
DOIs	https://doi.org/10.1016/0956-5663(93)80075-Z
Publication status	Published - 1 Jan 1993
Externally published	Yes

Keywords

ESPRIT
Human chorionic gonadotropin
Sub-micron latex particles
Surface plasmon resonance

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10.1016/0956-5663(93)80075-Z

Severs1993enhancedFinal published version, 492 KB

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abstract = "The pregnancy hormone human chorionic gonadotropin (hCG) was used as a model antigen to describe a new assay, the Enhanced Surface Plasmon Resonance Inhibition Test (ESPRIT). It was shown that the introduction of sub-micron latex particles instead of anti-antibodies in an enhancement step improved the sensitivity of the assay by a factor of 30. Latex particles are therefore considered to be versatile tools in the development of new immunochemical assays for the detection of any analyte using SPR immunosensors.",

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N2 - The pregnancy hormone human chorionic gonadotropin (hCG) was used as a model antigen to describe a new assay, the Enhanced Surface Plasmon Resonance Inhibition Test (ESPRIT). It was shown that the introduction of sub-micron latex particles instead of anti-antibodies in an enhancement step improved the sensitivity of the assay by a factor of 30. Latex particles are therefore considered to be versatile tools in the development of new immunochemical assays for the detection of any analyte using SPR immunosensors.

AB - The pregnancy hormone human chorionic gonadotropin (hCG) was used as a model antigen to describe a new assay, the Enhanced Surface Plasmon Resonance Inhibition Test (ESPRIT). It was shown that the introduction of sub-micron latex particles instead of anti-antibodies in an enhancement step improved the sensitivity of the assay by a factor of 30. Latex particles are therefore considered to be versatile tools in the development of new immunochemical assays for the detection of any analyte using SPR immunosensors.

KW - ESPRIT

KW - Human chorionic gonadotropin

KW - Sub-micron latex particles

KW - Surface plasmon resonance

U2 - 10.1016/0956-5663(93)80075-Z

DO - 10.1016/0956-5663(93)80075-Z

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ER -

Enhanced surface plasmon resonance inhibition test (ESPRIT) using latex particles

Abstract

Keywords

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