Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation

A.M. Bokkers, J.-B. Blondé, I. Lentacker, M. Versluis, G. Lajoinie, S. Le Gac*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Abstract

Here, we report on ultrasound mediated microbubble activation for efficient and deep delivery of nanomedicines in co-culture multicellular tumor spheroids (MCTS), in a microfluidic chip. Specifically, a tumor-on-a-chip platform was realized by trapping multi-cellular tumor spheroids in a microfluidic chamber. Microbubbles and nanoparticles, used as models for nanomedicines, were perfused continuously, the microbubbles were activated by ultrasound and the penetration of the nanoparticles was quantified. Our experiments reveal that the nanoparticle penetration sites coincide with the initial positions of the microbubbles around the spheroids.

Original languageEnglish
Title of host publicationMicroTAS 2018
Subtitle of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences
EditorsFan-Gang Tseng, Gwo-Bin Lee
PublisherThe Chemical and Biological Microsystems Society
Pages1620-1621
Number of pages2
Volume3
ISBN (Electronic)978-1-510-89757-1
ISBN (Print)978-0-578-40530-8
Publication statusPublished - 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Province of China
Duration: 10 Nov 201815 Nov 2018
Conference number: 22
https://cbmsociety.org/conferences/microtas2018/

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
Abbreviated titleMicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period10/11/1815/11/18
Internet address

Keywords

  • Microbubbles
  • Multi-cellular tumor spheroids
  • Nanomedicines
  • Ultrasound

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