Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation

A.M. Bokkers; J.-B. Blondé; I. Lentacker; M. Versluis; G. Lajoinie; S. Le Gac

Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation

A.M. Bokkers, J.-B. Blondé, I. Lentacker, M. Versluis, G. Lajoinie, S. Le Gac^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

Here, we report on ultrasound mediated microbubble activation for efficient and deep delivery of nanomedicines in co-culture multicellular tumor spheroids (MCTS), in a microfluidic chip. Specifically, a tumor-on-a-chip platform was realized by trapping multi-cellular tumor spheroids in a microfluidic chamber. Microbubbles and nanoparticles, used as models for nanomedicines, were perfused continuously, the microbubbles were activated by ultrasound and the penetration of the nanoparticles was quantified. Our experiments reveal that the nanoparticle penetration sites coincide with the initial positions of the microbubbles around the spheroids.

Original language	English
Title of host publication	MicroTAS 2018
Subtitle of host publication	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Editors	Fan-Gang Tseng, Gwo-Bin Lee
Publisher	The Chemical and Biological Microsystems Society
Pages	1620-1621
Number of pages	2
Volume	3
ISBN (Electronic)	978-1-510-89757-1
ISBN (Print)	978-0-578-40530-8
Publication status	Published - 2018
Event	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan Duration: 10 Nov 2018 → 15 Nov 2018 Conference number: 22 https://cbmsociety.org/conferences/microtas2018/

Conference

Conference	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
Abbreviated title	MicroTAS 2018
Country/Territory	Taiwan
City	Kaohsiung
Period	10/11/18 → 15/11/18
Internet address	https://cbmsociety.org/conferences/microtas2018/

Keywords

Microbubbles
Multi-cellular tumor spheroids
Nanomedicines
Ultrasound

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Bokkers, A. M., Blondé, J.-B., Lentacker, I., Versluis, M., Lajoinie, G., & Le Gac, S. (2018). Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation. In F.-G. Tseng, & G.-B. Lee (Eds.), MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (Vol. 3, pp. 1620-1621). The Chemical and Biological Microsystems Society.

Bokkers, A.M. ; Blondé, J.-B. ; Lentacker, I. et al. / Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation. MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. editor / Fan-Gang Tseng ; Gwo-Bin Lee. Vol. 3 The Chemical and Biological Microsystems Society, 2018. pp. 1620-1621

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abstract = "Here, we report on ultrasound mediated microbubble activation for efficient and deep delivery of nanomedicines in co-culture multicellular tumor spheroids (MCTS), in a microfluidic chip. Specifically, a tumor-on-a-chip platform was realized by trapping multi-cellular tumor spheroids in a microfluidic chamber. Microbubbles and nanoparticles, used as models for nanomedicines, were perfused continuously, the microbubbles were activated by ultrasound and the penetration of the nanoparticles was quantified. Our experiments reveal that the nanoparticle penetration sites coincide with the initial positions of the microbubbles around the spheroids.",

keywords = "Microbubbles, Multi-cellular tumor spheroids, Nanomedicines, Ultrasound",

author = "A.M. Bokkers and J.-B. Blond{\'e} and I. Lentacker and M. Versluis and G. Lajoinie and {Le Gac}, S.",

year = "2018",

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editor = "Fan-Gang Tseng and Gwo-Bin Lee",

booktitle = "MicroTAS 2018",

publisher = "The Chemical and Biological Microsystems Society",

note = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, MicroTAS 2018 ; Conference date: 10-11-2018 Through 15-11-2018",

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Bokkers, AM, Blondé, J-B, Lentacker, I, Versluis, M , Lajoinie, G & Le Gac, S 2018, Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation. in F-G Tseng & G-B Lee (eds), MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. vol. 3, The Chemical and Biological Microsystems Society, pp. 1620-1621, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, Kaohsiung, Taiwan, 10/11/18.

Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation. / Bokkers, A.M.; Blondé, J.-B.; Lentacker, I. et al.
MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. ed. / Fan-Gang Tseng; Gwo-Bin Lee. Vol. 3 The Chemical and Biological Microsystems Society, 2018. p. 1620-1621.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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AU - Bokkers, A.M.

AU - Blondé, J.-B.

AU - Lentacker, I.

AU - Versluis, M.

AU - Lajoinie, G.

AU - Le Gac, S.

N1 - Conference code: 22

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N2 - Here, we report on ultrasound mediated microbubble activation for efficient and deep delivery of nanomedicines in co-culture multicellular tumor spheroids (MCTS), in a microfluidic chip. Specifically, a tumor-on-a-chip platform was realized by trapping multi-cellular tumor spheroids in a microfluidic chamber. Microbubbles and nanoparticles, used as models for nanomedicines, were perfused continuously, the microbubbles were activated by ultrasound and the penetration of the nanoparticles was quantified. Our experiments reveal that the nanoparticle penetration sites coincide with the initial positions of the microbubbles around the spheroids.

AB - Here, we report on ultrasound mediated microbubble activation for efficient and deep delivery of nanomedicines in co-culture multicellular tumor spheroids (MCTS), in a microfluidic chip. Specifically, a tumor-on-a-chip platform was realized by trapping multi-cellular tumor spheroids in a microfluidic chamber. Microbubbles and nanoparticles, used as models for nanomedicines, were perfused continuously, the microbubbles were activated by ultrasound and the penetration of the nanoparticles was quantified. Our experiments reveal that the nanoparticle penetration sites coincide with the initial positions of the microbubbles around the spheroids.

KW - Microbubbles

KW - Multi-cellular tumor spheroids

KW - Nanomedicines

KW - Ultrasound

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M3 - Conference contribution

SN - 978-0-578-40530-8

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EP - 1621

BT - MicroTAS 2018

A2 - Tseng, Fan-Gang

A2 - Lee, Gwo-Bin

PB - The Chemical and Biological Microsystems Society

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Y2 - 10 November 2018 through 15 November 2018

ER -

Bokkers AM, Blondé JB, Lentacker I, Versluis M , Lajoinie G , Le Gac S. Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation. In Tseng FG, Lee GB, editors, MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Vol. 3. The Chemical and Biological Microsystems Society. 2018. p. 1620-1621

Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation

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