This article presents a numerical study of natural convection cooling of a heat source mounted inside the cavity, with special attention being paid to entropy generation. The right vertical wall is partially open and is subjected to copper-water nanofluid at a constant low temperature and pressure, while the other boundaries are assumed to be adiabatic. The governing equations have been solved using the finite volume approach, using SIMPLE algorithm on the collocated arrangement. The study has been carried out for a Rayleigh number in the range 10 3 < Ra < 10 6, and for solid volume fraction 0 <φ <0.05. In order to investigate the effect of the heat source and open boundary location, six different configurations are considered. The effects of Rayleigh numbers, heat source and open boundary locations on the streamlines, isotherms, local entropy generation, Nusselt number, and total entropy generation are investigated. The results indicate that when open boundary is located up, the fluid flow augments and hence the heat transfer and Nusselt number increase and total entropy generation decreases.