Environment-friendly transesterification to seawater-degradable polymers expanded: Computational construction guide to breaking points

Mateusz Pokora, Timo Rheinberger, Frederik R. Wurm, Agata Paneth, Piotr Paneth*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
52 Downloads (Pure)

Abstract

Marine plastic pollution caused by non-biodegradable polymers is a major worldwide concern. So-called “biodegradable” polymers should reduce plastic pollution in the environment by the safeguard of biodegradation. However, many polyesters degrade very slowly in seawater. We therefore designed a systematic library of “breaking points” that are installed into a polylactide backbone and simulated their degradation mechanisms, including internal and external SN2 mechanisms, Addition-Elimination (AE) mechanisms, and RNA-inspired mechanisms. The breaking points are composed of phosphoesters with pendant nucleophiles directly at the P-atom, or structurally similar silicones, or side-chain functional polyesters. All P-containing breaking points react via the RNA-inspired mechanism, while Si-containing linkers undergo decomposition via the A-E mechanism. For C-containing linkers, only when a long pendant chain (4 carbon atoms) is present can the reaction proceed via the RNA-inspired mechanism. In cases of shorter pendants, the Addition-Elimination (AE) mechanism is energetically favorable. We believe that these calculations will pave the way for the synthesis of exceptionally seawater-degradable polyesters in the future that can act as a safeguard to prevent microplastic formation after eventual littering.

Original languageEnglish
Article number136381
JournalChemosphere
Volume308
Issue numberPart 2
Early online date8 Sept 2022
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Degradable polymers
  • DFT calculations
  • Intramolecular transesterification
  • Marine litter

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