Enzymes containing porous polymersomes as nano reaction vessels for cascade reactions

S. Kuiper, Madhavan Nallani, D.M. Vriezema, Jeroen Johannes Lambertus Maria Cornelissen, Jan van Hest, Roeland Nolte, A.E. Rowan

Research output: Contribution to journalArticleAcademicpeer-review

103 Citations (Scopus)


Polystyrene40-b-poly(isocyanoalanine(2-thiophen-3-yl-ethyl)amide)50 (PS-PIAT) polymersomes have the unique property of being sufficiently porous to allow diffusion of small (organic) substrates while retaining large biomolecules such as enzymes inside. Herein we report on the encapsulation and protection of glucose oxidase (GOx) and horse radish peroxidase (HRP) in PS-PIAT polymersomes and the successful employment of these functionalised nanoreactors in a cascade reaction. The demonstrated concept allows for further application in other enzymatic cascade reactions, bio-organic hybrid systems and biosensing devices.
Original languageUndefined
Pages (from-to)4315-4318
JournalOrganic & biomolecular chemistry
Publication statusPublished - 2008


  • METIS-306511

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