Epidural spinal cord stimulation: calculation of field potentials with special reference to dorsal column nerve fibers

Johannes J. Struijk; Jan Holsheimer; Benno K. van Veen; Herman B.K. Boom

doi:10.1109/10.68217

Epidural spinal cord stimulation: calculation of field potentials with special reference to dorsal column nerve fibers

Johannes J. Struijk, Jan Holsheimer, Benno K. van Veen, Herman B.K. Boom

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The effect of electrical stimulation with several electrode combinations on nerve fibers with different orientations in the spinal cord was investigated by computing the steady-state field potentials and activating functions. An infinite homogeneous model was used, and the spinal cord and its surrounding tissues where then modeled as an inhomogeneous anisotropic volume conductor. The effect of mediodorsal epidural stimulation was calculated. It was concluded that the cathodal stimulation, mediodorsally in the epidural space, longitudinal fibers are depolarized, but dorsoventral ones are hyperpolarized. With anodal stimulation the opposite will occur. It was found that parameters substantially affecting the potential distribution in the dorsal columns are the conductivity of the white matter and the width and the conductivity of the cerebrospinal fluid layer

Original language	English
Pages (from-to)	104-110
Number of pages	7
Journal	IEEE transactions on biomedical engineering
Volume	38
Issue number	1
DOIs	https://doi.org/10.1109/10.68217
Publication status	Published - 1991

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title = "Epidural spinal cord stimulation: calculation of field potentials with special reference to dorsal column nerve fibers",

abstract = "The effect of electrical stimulation with several electrode combinations on nerve fibers with different orientations in the spinal cord was investigated by computing the steady-state field potentials and activating functions. An infinite homogeneous model was used, and the spinal cord and its surrounding tissues where then modeled as an inhomogeneous anisotropic volume conductor. The effect of mediodorsal epidural stimulation was calculated. It was concluded that the cathodal stimulation, mediodorsally in the epidural space, longitudinal fibers are depolarized, but dorsoventral ones are hyperpolarized. With anodal stimulation the opposite will occur. It was found that parameters substantially affecting the potential distribution in the dorsal columns are the conductivity of the white matter and the width and the conductivity of the cerebrospinal fluid layer",

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AU - van Veen, Benno K.

AU - Boom, Herman B.K.

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AB - The effect of electrical stimulation with several electrode combinations on nerve fibers with different orientations in the spinal cord was investigated by computing the steady-state field potentials and activating functions. An infinite homogeneous model was used, and the spinal cord and its surrounding tissues where then modeled as an inhomogeneous anisotropic volume conductor. The effect of mediodorsal epidural stimulation was calculated. It was concluded that the cathodal stimulation, mediodorsally in the epidural space, longitudinal fibers are depolarized, but dorsoventral ones are hyperpolarized. With anodal stimulation the opposite will occur. It was found that parameters substantially affecting the potential distribution in the dorsal columns are the conductivity of the white matter and the width and the conductivity of the cerebrospinal fluid layer

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