Epidural spinal cord stimulation: calculation of field potentials with special reference to dorsal column nerve fibers

Johannes J. Struijk, Jan Holsheimer, Benno K. van Veen, Herman B.K. Boom

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    60 Citations (Scopus)
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    Abstract

    The effect of electrical stimulation with several electrode combinations on nerve fibers with different orientations in the spinal cord was investigated by computing the steady-state field potentials and activating functions. An infinite homogeneous model was used, and the spinal cord and its surrounding tissues where then modeled as an inhomogeneous anisotropic volume conductor. The effect of mediodorsal epidural stimulation was calculated. It was concluded that the cathodal stimulation, mediodorsally in the epidural space, longitudinal fibers are depolarized, but dorsoventral ones are hyperpolarized. With anodal stimulation the opposite will occur. It was found that parameters substantially affecting the potential distribution in the dorsal columns are the conductivity of the white matter and the width and the conductivity of the cerebrospinal fluid layer
    Original languageEnglish
    Pages (from-to)104-110
    Number of pages7
    JournalIEEE transactions on biomedical engineering
    Volume38
    Issue number1
    DOIs
    Publication statusPublished - 1991

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