Estimation in a growth study with irregular measurement times

Klaas Poortema, R.Y.J. Tamminga, W. Schaafsma

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    Between 1982 and 1988 a growth study was carried out at the Division of Pediatric Oncology of the University Hospital of Groningen. A special feature of the project was that sample sizes are small and that ages at entry may be very different. In addition the intended design was not fully complied with. This paper highlights some aspects of the statistical analysis which is based on (1) reference scores, (2) statistical procedures allowing for an irregular pattern of measurement times caused by missing data and shifted measurement times.
    Original languageUndefined
    Pages (from-to)89-95
    Number of pages7
    JournalStatistica Neerlandica
    Issue number2
    Publication statusPublished - 1993


    • expectations and variances with linear structure
    • iterative generalized least squares
    • METIS-140685
    • Growth curves
    • IR-71005

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