Estimation of x-ray parameters in digital coronary angiography for compensation of myocardial perfusion measurements

C.J. Storm, Cornelis H. Slump

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    1 Citation (Scopus)


    Coronary angiography is the primary technique for diagnosing coronary abnormalities as it is able to locate precisely the coronary artery lesions. However, the clinical relevance of an appearing stenosis is not that easy to assess. In previous work we have analyzed the myocardial perfusion by comparing basal and hyperemic coronary flow. This comparison is the basis of a Relative Coronary Flow Reserve (RCFR) measure. In a Region-of-Interest (ROI) on the angiogram the contrast is measured as a function of time (the so-called time-density curve). The required hyperemic state of exercise is induced artificially by the injection of a vasodilator drug e.g. papaverine. In previous work we have presented the results of a small study of 20 patients. In this paper we present an analysis of the sensitivity of the method for variations in Xray exposure between the two runs due to the Automatic Exposure Control (AEC) unit. The AEC is a system unit with the task to ensure a constant dose rate at the entrance of the detector by making the appropriate adaptations in X-ray factor settings for patients which range from slim to more obese. We have setup a phantom study to reveal the expected exposure variations. We present several of the developed phantoms together with a compensation strategy.
    Original languageUndefined
    Title of host publicationProceedings of SPIE Medical imaging
    EditorsJ. Hsieh, E. Samei
    Place of PublicationUSA
    Number of pages12
    ISBN (Print)978-0-8194-7105-5
    Publication statusPublished - 16 Feb 2008
    EventSPIE Medical Imaging 2008 - Town & Country Resort and Convention Center, San Diego, United States
    Duration: 16 Feb 200821 Feb 2008

    Publication series

    ISSN (Print)0277-786X


    ConferenceSPIE Medical Imaging 2008
    CountryUnited States
    CitySan Diego


    • EWI-15147
    • METIS-256460
    • IR-62758

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