Evaluation of a cardiac flow phantom for absolute myocardial perfusion SPECT measurements

M. E. Kamphuis*, Marcel J.W.G. Greuter, Riemer J.H.A. Slart, Cornelis H. Slump

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Abstract

Absolute myocardial perfusion imaging (MPI) can be beneficial in the diagnosis and prognosis of patients with coronary artery disease. However, validation and standardization of perfusion estimates across centers is needed to ensure safe and adequate integration into clinical routine. MPI phantoms can contribute to this clinical need as these models can provide ground truth evaluation of absolute MPI in a simplified, though controlled setup. This work presents verification of phantom design choices, including the justification for using sorbents in mimicking contrast kinetics (i.e., tracer uptake and retention). Moreover, we compare preliminary phantom results obtained with SPECT-MPI with a patient example. Finally, we applied a general two-tissue compartment model to describe the obtained phantom time activity curve data. These evaluation steps support shaping of a suitable verification and validation strategy for the multimodal myocardial perfusion phantom design and realization.

Original languageEnglish
Title of host publicationMedical Imaging 2022
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor S. Gimi, Andrzej Krol
PublisherSPIE
ISBN (Electronic)9781510649477
ISBN (Print)978-1-5106-4947-7
DOIs
Publication statusPublished - 4 Apr 2022
EventSPIE Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling - Virtual, Online
Duration: 21 Mar 202227 Mar 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12036
ISSN (Print)1605-7422

Conference

ConferenceSPIE Medical Imaging 2022
CityVirtual, Online
Period21/03/2227/03/22

Keywords

  • ground truth
  • model verification
  • myocardial perfusion
  • phantom
  • quantitative imaging
  • SPECT
  • tracer kinetics

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