Evaluation of Exacerbation and Symptom-Free Time in Patients with COPD

Mirthe de Vries, Tanja W. Effing, Job van der Palen, Jade Schrijver, Paul D.L.P.M. van der Valk, Anke Lenferink*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

55 Downloads (Pure)


In clinical practice, clinicians mainly focus on Chronic Obstructive Pulmonary Disease (COPD) exacerbations and symptoms, while patients may prefer to evaluate periods free of COPD exacerbations and deteriorated symptoms. The latter would suit the positive health approach that centralizes people and their beliefs. We aimed to identify patient characteristics and health outcomes relating to: 1) COPD exacerbation-free days; 2) days with no more symptoms than usual; and 3) combined COPD exacerbation and comorbid flare-up-free days (i.e. chronic heart failure, anxiety, depression flare-ups) using negative binomial regression analyzes. Data were obtained from two self-management intervention trials including COPD patients with and without comorbidities. 313 patients (mean age 66.0 years, 63.6% male, 68.7% comorbidity) were included. Better baseline chronic respiratory questionnaire (CRQ) fatigue (incidence rate ratio (IRR) = 1.03 (95% CI 1.01–1.05), p = 0.02) and mastery scores (IRR = 1.03 (95% CI 1.00–1.06), p = 0.04) and fewer courses of antibiotics (IRR = 0.95 (95% CI 0.94–0.96), p 
Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
Issue number1
Publication statusPublished - 1 Dec 2023


  • UT-Hybrid-D


Dive into the research topics of 'Evaluation of Exacerbation and Symptom-Free Time in Patients with COPD'. Together they form a unique fingerprint.

Cite this